Thromboelastography-Guided Transfusion Algorithm Reduces Transfusions in Complex Cardiac Surgery

A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery

“…These results are in accordance with previous studies demonstrating that hemostatic blood product requirement is significantly reduced by the use of a transfusion algorithm based on coagulation testing. 11,36 Finally, the marked reduction in allogeneic blood transfusion did not seem to be associated with any increase in postoperative morbidity or mortality, as already observed in other studies. 1,15,33 The lack of randomization represents a limitation of our study.…”

Methods for evaluation of platelet function

“…Also for the ROTEM ® instrument, different commercial reagents are available, with tissue factor, with aprotinin to detect hyperfibrinolysis or with GPIIb/IIIa antagonists to evaluate the fibrin network contribution to the clot strength, with contact activator or with heparinase for the use during heparin treatment. TEG has been used to monitor blood component therapy during surgery [21][22][23][24]. Free oscillation rheometry (FOR) (MediRox AB, Sweden) is a new technology which makes it possible for the first time both to measure changes in viscosity and elasticity in clotting whole blood and in dissolving clots and to obtain results in real time in SI-units.…”

Traffic politraumatised patient: 'Life is a journey, not a destination': Traffic polytrauma

“…23 Dalja korekcija koagulopatije vođena je primenom rotacione tromboelastometrije (ROTEM). 24,25,26 Hipotermija je korigovana grejanjem pacijenta sistemom sa toplim vazduhom, a acidoza optimizacijom hemodinamike inotropnom podrškom noradrenalinom. Naš pacijent se četvrtog postoperativnog dana suočio sa sepsom plućnog porekla uz pozitivan prokalcitoninski test, koji je ujedno služio i za praće-nje odgovora na primenjenu antibiotsku terapiju.…”