Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor

Abstract

There is increasing evidence that thrombocytosis is associated with tumor invasion and metastasis formation. It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to evaluate preoperative thrombocytosis as a potential prognostic biomarker in isolated metastases, in patients with liver metastasis of colorectal cancer (mCRC). Clinicopathological data of 166 patients with mCRC who had surgical resection between 2001 and 2011 were collected retrospectively. All primary tumors have been already resected. The platelet count was evaluated based on the standard preoperative blood profile. The patients were followed-up on average for 28 months. Overall survival (OS) of patients with thrombocytosis was significantly worse both in univariate (HR = 3.00, p = 0.03) and in multivariate analysis (HR = 4.68, p = 0.056) when adjusted for gender, age, tumor size and surgical margin. Thrombocytosis was also a good prognosticator of disease-free survival (DFS) with HR = 2.7, p = 0.018 and nearly significant in multivariate setting (HR = 2.26, p = 0.073). The platelet count is a valuable prognostic marker for the survival in patients with mCRC.

Thrombocytosis Portends Adverse Prognosis in Colorectal Cancer: A Meta-Analysis of 5,619 Patients in 16 Individual Studies

“…of note, we used a randomeffects model in the presence of heterogeneity (i 2 =66.5%, p<0.001). The studies proposing a strong poor prognostic role of thrombocytosis in cRc included those of cravioto-Villanueva et al (43), Kaneko et al (20), Jósa et al (45), and Toiyama et al (21). For DFs, a greater HR was observed in our study cohort (HR=1.96, 95% ci=1.23-2.69) with a random-effects model (i 2 =69.3%, p=0.002).…”

Poor prognostic role of the pretreatment platelet counts in colorectal cancer

“…Finally, this meta-analysis included 9 retrospective cohort studies comprising 3413 patients with colorectal cancer. [ 5 , 10 , 15 , 24 – 29 ]…”

Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis

“…Early in 1998, Monreal M et al reported a significant association between pre-operative platelet count and survival in patients with colorectal cancer. The following studies confirmed this association [2, 3, 5, 6]. However, some other studies failed to demonstrate the association between pretreatment elevated platelet count and outcomes of colorectal cancer [11–16].…”