Thrombocytopenia in the neonatal lupus syndrome

Watson, Rosemarie

doi:10.1001/archderm.124.4.560

Cited by 38 publications

(18 citation statements)

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“…Although thrombocytopenia has been noted in approximately 10% of NLE cases presenting with other forms of NLE manifestation, it typically occurs very infrequently as the sole form of NLE manifestation and is usually transient and unproblematic [30]. In this study, 7 patients (35%) were found to have experienced hematological abnormalities, including pancytopenia, thrombocytopenia, and anemia but all had recovered from these abnormalities within several weeks, as determined by testing that indicated a normal blood cell count level.…”

Section: Hepatobiliary Abnormalitymentioning

confidence: 62%

Neonatal Lupus Erythematosus in South Korea: Clinical and Serologic Features

Lee¹,

Sim²,

Park³

et al. 2014

J Clin Exp Dermatol Res

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Background: Neonatal lupus erythematosus (NLE) is an autoimmune disease associated with maternal anti-SS-A/ Ro and anti-SS-B/La antibodies and characterized by cutaneous erythema, congenital heart block (CHB), hepatic dysfunction, and hematological abnormalities.Aim: This study aimed to identify the clinical characteristics of cases of NLE among South Koreans by analysis of data reported in the literature and in the medical records of 1 NLE patient at our hospital and compare them to the clinical characteristics of NLE among Caucasians, as reported in the literature. Methods:The clinical data regarding 1 patient diagnosed with NLE at our hospital and those of 19 patients diagnosed with NLE at other South Korean hospitals between 1993 and 2010 were reviewed and analyzed before being compared with those regarding Caucasians diagnosed with NLE, as reported in the literature.Results: Regarding onset of manifestation, 80% of NLE patients in South Korea began to display clinical characteristics of NLE within 4 weeks of diagnosis. Regarding the form of clinical manifestation, 80% manifested skin abnormality; 25%, CHB; 35%, hematologic abnormality; and 25%, transient elevated transaminase level. These percentages were comparable to those reported for Caucasian NLE cases. Whereas the literature indicates a female predominance in NLE incidence among Caucasians, analysis of the study data indicates a male predominance in NLE incidence among South Koreans. Conclusions:Other than that for CHB, the incidence of each form of NLE manifestation is relatively similar for South Korean and Caucasian NLE cases. The major difference between the incidence of NLE between South Koreans and Caucasians concerns the male:female ratio, which appears higher for South Koreans, and to indicate a male predominance in NLE incidence among South Koreans.

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Section: Hepatobiliary Abnormalitymentioning

confidence: 62%

Neonatal Lupus Erythematosus in South Korea: Clinical and Serologic Features

Lee¹,

Sim²,

Park³

et al. 2014

J Clin Exp Dermatol Res

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show abstract

“…Hepatitis, hyperbilirubinemia, liver failure, thrombocytopenia, and anemia can occur [2][3][4][5][6][7][8][9][10] . The prognosis of a NLE patient with liver failure is poor, whereas for the NLE patients with other manifestations, the prognosis is good with transient involvement and spontaneous resolution.…”

Section: Discussionmentioning

confidence: 99%

A Case of Neonatal Lupus Erythematosus Showing Transient Anemia and Hepatitis

Kim

Yoon

2009

Ann Dermatol

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“…Liver manifestations usually include elevated liver enzymes, hepatomegaly and splenomegaly [91,92]. Hematologic manifestations may include neutropenia [93] and/or thrombocytopenia [94]. It has been noted that thrombocytopenia can be associated with transfer of maternal anti-platelet antibodies across the placenta [95].…”

Section: 2mentioning

confidence: 99%

Neonatal autoimmune diseases: A critical review

Chang

2012

Journal of Autoimmunity

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Thrombocytopenia in the neonatal lupus syndrome

Cited by 38 publications

References 0 publications

Neonatal Lupus Erythematosus in South Korea: Clinical and Serologic Features

Neonatal Lupus Erythematosus in South Korea: Clinical and Serologic Features

A Case of Neonatal Lupus Erythematosus Showing Transient Anemia and Hepatitis

Neonatal autoimmune diseases: A critical review

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