Thrombocytopenia in Neonates With Trisomy 21

Descriptive study of the complete blood count in newborn infants with Down syndrome

“…Its cause in DS may involve bone marrow dysregulation or an increase in peripheral destruction or consumption [Dixon et al, ]. Hord et al [] found that cyanotic congenital heart disease in newborn infants with DS did not increase the frequency of thrombocytopenia, as has been suggested previously in infants without DS [Wedemeyer et al, ]. The degree of thrombocytopenia has also been related to the severity of the polycythemia in one study [Henry et al, ], but neither Jackson et al [] nor our study confirmed this.…”

Platelet count and mean platelet volume predict outcome in adults with Eisenmenger syndrome

“…Patients with DS are known to have a relatively high incidence of haematological disorders and leukaemia, including transient abnormal myelopoiesis or megakaryocytic dysregulation 27. Our data suggest that the mechanism behind lower platelet counts in patients with DS compared with their non-Down counterparts is not related to abnormalities in the platelet maturation process; indeed, there was no difference in MPV between the two groups.…”

A relationship between subclinical hypothyroidism and hematologic parameters in patients with Down Syndrome

“…In the study of Miller et al [10] which evaluated 81 infants with DS, hematological evaluation was done in 61 infants, and 33 had a normal hematological status, and 28 (46%) had at least one abnormality, including hematocrit, white cell count, or platelet count. Hord et al reported that 66% of 25 newborns with DS had thrombocytopenia in their study [11].…”