Thrombocytopenia in neonatal sepsis: Incidence, severity and risk factors

Ree, Isabelle M C; Fustolo-Gunnink, Suzanne; Bekker, Vincent; Fijnvandraat, Karin; Steggerda, Sylke J.; Lopriore, Enrico

doi:10.1371/journal.pone.0185581

Cited by 86 publications

(80 citation statements)

References 22 publications

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“…Furthermore, the most commonly isolated organisms in septic neonates were gram negative (E. coli and Klebsiella) in 55% of cases. These results agree well with Ree et al [17], as they found that severe NT occurred in 20% of septic neonates and the most commonly isolated organisms were gram negative. The pathogenesis of NT in neonatal sepsis is not completely understood.…”

Section: Discussionsupporting

confidence: 92%

Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

Saber

Aziz

Almasry

et al. 2020

Preprint

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Background Neonatal thrombocytopenia (NT) is a common finding in the neonatal intensive care unit (NICU). The main aim of this study was to assess the prevalence, rick factors and outcomes of severe NT in full term (FT) infants. Method: During the study period, all FT infants who met the inclusion criteria for NT on two occasions were included. Maternal data such as maternal age, weight, gestational age, mode of delivery, and history of systemic diseases were recorded. Furthermore, neonatal data such as gender, neonatal weight, causes/duration of admission, types of respiratory support used, blood count and outcomes for neonates admitted to the NICU were recorded. Results In total, 55 FT infants with NT met the inclusion criteria. In all, 29 (52.73%) cases had severe NT. The most common cause of NT was neonatal sepsis (20 cases, 37.03%), followed by a postoperative state (5 cases, 9.25%). Moreover, in cases of positive blood cultures, the most commonly isolated organism was Escherichia coli (6 cases, 10.90%), followed by Klebsiella (5 cases, 9.09%). Cases of severe NT, when compared to cases of mild/moderate NT associated with signs of bleeding and pulmonary/intraventricular hemorrhage (IVH) (P = 0.001), needed more platelet transfusions (P = 0.001) and had higher rates of mortality (P = 0.001). Conclusion Severe NT occurred in 52.73% of cases. The most common cause of NT was neonatal sepsis, followed by a postoperative state. Furthermore, severe NT, when compared to mild/moderate NT associated with signs of bleeding and pulmonary/IVH, needed more platelet transfusions and had increased mortality.

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Section: Discussionsupporting

confidence: 92%

Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

Saber

Aziz

Almasry

et al. 2020

Preprint

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“…80% of neonates, in addition to multiple organ failure, presented a hemorrhagic syndrome, with thrombocytopenia; this is reported also in the literature [22][23][24][25] . The elevated level of C-reactive protein, as a marker of the infectious-inflammatory process of the newborn, was noted in only three children (12%) with early neonatal sepsis.…”

Section: Discussionsupporting

confidence: 55%

Clinical‑anamnestic peculiarities of the course of neonatal sepsis in newborns

Vlasova¹,

Koliubakina²,

Krecu³

2018

Arch Balk Med Union

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“…Thrombocytopenia is one of these (3). Thrombocytopenia occurs in half of the cases with proven sepsis (10) and is used as a marker for screening of neonatal sepsis. It has been reported to be more common in association with some sepsis causing germs.…”

Section: Discussionmentioning

confidence: 99%

Platelets Indices and Different Germs of Neonatal Sepsis

et al. 2019

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Background: Due to high incidence of sepsis as the main cause of neonatal mortality, early detection and proper treatment are important in reducing of neonatal mortality. Therefore, researchers are looking for a way of early diagnosis and treatment of sepsis. Platelet indices are one of these ways. But, can they determine different causing germs of neonatal sepsis? Methods: In this study, the septic neonates with positive blood culture were studied. Neonates with positive blood culture were divided into three groups; Gram-positive, Gram-negative and fungal infections. Platelet count and other parameters of platelets including PDW (platelet distribution width), and MPV (mean platelet volume) were evaluated, and compared with respect to different germs of septic neonates. Results: In this study 99 newborns with positive blood cultures were evaluated. Of these 13 neonates were excluded because of contaminated culture. In the remaining 86 cases thrombocytopenia, thrombocytosis, PDW, and MPV in different types of neonatal sepsis were evaluated and compared. Conclusions: Although thrombocytosis may be a laboratory finding for sepsis but it is not common in early onset sepsis. Elevated PDW is more common in Gram-negative infections and may be helpful in determining different germs of neonatal sepsis but mean values of PDW in Gram-negative infections are not more than that caused by other germs.

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Thrombocytopenia in neonatal sepsis: Incidence, severity and risk factors

Cited by 86 publications

References 22 publications

Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

Risk Factors For Severity Of Thrombocytopenia In Full Term Infants: A Single Center Study

Clinical‑anamnestic peculiarities of the course of neonatal sepsis in newborns

Platelets Indices and Different Germs of Neonatal Sepsis

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