Thrombocytopenia Due to Quinidine or Quinine

Weerdt, Ch.M. van der; Riesz, L.E. With technical assistance of Veenhoven-von

doi:10.1159/000464609

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…In presence of quinine the PF 3 and acid phosphatase activi ties are made available in the patient's PRP. Similar results using the complement fixation test have been published by van der Weerdt [21]. It may, therefore, be possible to detect drug dependent antibodies years after recovery from acute allergic thrombocytopenia.…”

Section: Discussionsupporting

confidence: 82%

Diagnosis of Quinine Hypersensitivity, Use of Platelet Factor 3 and Acid Phosphatase Availability Tests

Polasek

Duckert

1971

Acta Haematol

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Two patients with a known quinine induced allergic thrombocytopenia have been studied in order to detect in vitro the presence of drug-dependent antibodies in their plasma. The platelet factor 3 and platelet acid phosphatase availability tests have shown that these antibodies are still present several years after the last exposition to quinine followed by the typical clinical symptoms. The demasking of acid phosphatase activity is increased in presence of calcium ions. The possible mechanisms leading to the demasking of PF 3 and acid phosphatase after exposition of the patient’s platelets to quinine are discussed

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Section: Discussionsupporting

confidence: 82%

Diagnosis of Quinine Hypersensitivity, Use of Platelet Factor 3 and Acid Phosphatase Availability Tests

Polasek

Duckert

1971

Acta Haematol

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“…Drug-induced thrombocytopenia must be considered as a dangerous condition. Even small amounts of the sensitizing drug may elicit severe thrombocytopenia (4,8). No specific treatment is available, but it is essential to withdraw the drug immediately.…”

Section: Discussionmentioning

confidence: 99%

Immune Thrombocytopenia Due to Antazoline (Antistina®)

Nielsen

Dahl

Kissmeyer-Nielsen

1981

Allergy

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Antazoline (Antistina)-induced thrombocytopenic purpura occurring on three occasions in a 21-year-old woman is reported. After withdrawal of the drug ther recovered promptly. In vitro investigation demonstrated the presence of an antibody in serum, which in association with antazoline caused complement fixation when added to test platelets. Also platelet agglutinins could be detected in the patient's serum when antazoline was added. The reactions were drug specific and they could still be demonstrated 9 months after the last exposure to the drug.

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“…In the acutely ill it may manifest as bleeding around catheter insertion sites, petechiae, ecchymoses, or bleeding from the gums and nose, and may extend to life-threatening gastrointestinal or intracranial hemorrhage. 4,5 Gastrointestinal hemorrhage may be suspected in a patient with a rapid fall in hemoglobin in the absence of obvious signs of bleeding. Although relatively uncommon, intracranial bleeding should be suspected in a severely thrombocytopenic patient with a new-onset neurologic defect.…”

Section: Clinical Featuresmentioning

confidence: 99%

Evaluation and Management of Drug‐Induced Thrombocytopenia in the Acutely Ill Patient

Wazny

Ariano

2000

Pharmacotherapy

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The numerous drugs to which the acutely ill are exposed place these patients at a significant risk of developing drug-induced thrombocytopenia. Such patients tend to have preexisting hemostatic defects that place them at additional risk of complications as a result of the drug-induced thrombocytopenia. The clinical challenge is to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis results. Drug-induced thrombocytopenic disorders can be classified into three mechanisms: bone marrow suppression, immune-mediated destruction, and platelet aggregation. Clinical characteristics, preliminary laboratory findings, and drug history specific to the mechanisms can assist clinicians in rapidly isolating the causative drug.

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Thrombocytopenia Due to Quinidine or Quinine

Cited by 7 publications

References 9 publications

Diagnosis of Quinine Hypersensitivity, Use of Platelet Factor 3 and Acid Phosphatase Availability Tests

Diagnosis of Quinine Hypersensitivity, Use of Platelet Factor 3 and Acid Phosphatase Availability Tests

Immune Thrombocytopenia Due to Antazoline (Antistina®)

Evaluation and Management of Drug‐Induced Thrombocytopenia in the Acutely Ill Patient

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