Three year evaluation of Xpert MTB/RIF in a low prevalence tuberculosis setting: A Scottish perspective

Parcell, Benjamin J.; Jarchow-MacDonald, Anna; Seagar, Amie-Louise; Laurenson, Ian F.; Prescott, Gordon; Lockhart, Michael

doi:10.1016/j.jinf.2017.02.005

Cited by 11 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study of Parcell B.J. et al ( 2017), with increasing the degree of smear (+1, +2, +3 or +4), the frequency of consolidation increased significantly( in degrees +1, +2, +3, the frequency of consolidation was +4 81%, 95%, 100% respectively) [14]. In the study of Brahmapurkar K.P.…”

Section: Discussionmentioning

confidence: 95%

Sputum smear positivity grade and chest X-ray findings in tuberculosis: a cross-sectional study

Behzadmehr¹,

Nejadkehkha²

2022

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

Despite many advances in the diagnosis, screening, and rapid treatment of tuberculosis, it is still a public health concern in the world. Due to the importance of this issue in diagnosis and reduction of transmission of infection and treatment of the disease especially where this study is conducted due to the high prevalence of tuberculosis, this study was done to determine The relationship between sputum smear positivity grade and chest X-ray findings in pulmonary tuberculosis patients in a hospital in southeast of Iran. This cross-sectional study was performed on all patients with pulmonary TB referencing the health centers in Zabol city, southeast of Iran from 1 January 2015 to 30 December 2020. Sputum smear and radiographic findings of the chest X-ray were evaluated. Data was collected using a form of information and finally analyzed by SPSS 22. Out of 101 patients examined in the present study, 71 were women and 30 were men. The mean age of the patients was 62.68 ± 13.61 years. The frequency of opacity in patients with grades 1, 2, and 3 was 71.4, 78.5, and 76.5%, respectively. Frequency of cavitation in patients with Grade 1, 2 and 3 was 11.5%, 28.5% and 52.9% respectively (P value 0.001). The frequency of reticulonodular presentations in patients with grade 1, 2, and 3 was 24.2, 7.1, and 0%, respectively. In general, the results of this study showed that, with increasing grading of smears (1+, 2+, and 3+), the frequency of cavitation presentation increased significantly and the frequency of reticulonodular presentations decreased significantly. In general, the results of this study showed that, with increasing grading of smears (, the frequency of Cavitation presentation increased significantly and the frequency of reticulonodular presentations decreased significantly. The findings of the present study can help physicians better diagnose TB.

show abstract

Section: Discussionmentioning

confidence: 95%

Sputum smear positivity grade and chest X-ray findings in tuberculosis: a cross-sectional study

Behzadmehr¹,

Nejadkehkha²

2022

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

show abstract

“…Akciğer örnekleri için GX testinin duyarlılığı %82.7, özgüllüğü %98.7 bulundu. Aralarında meta-analizlerin de bulunduğu dünyada yapılan çeşitli çalışmalarda, akciğer örneklerinde GX testinin duyarlılığı %58-100, özgüllüğü %86-100 arasında geniş bir yelpazede dağılmaktadır (5,16,19,20) . (20) ile Parcell ve ark.…”

Section: Mgit Sire Yöntemiunclassified

“…(20) ile Parcell ve ark. (19) tarafından yapılan çalışmalara göre düşük olduğu gözlenmektedir. Çalışmamızda kültürde MTK üremesi saptanıp GX testi ile MTK DNA'sı saptanmayan balgam örneklerinin tümü ARB negatif örneklerdi.…”

Section: Mgit Sire Yöntemiunclassified

See 1 more Smart Citation

Comparison of a Rapid Molecular Method with Conventional Methods for Identification of Mycobacterium tuberculosis complex and Detection of Rifampicin Resistance

Özkarataş¹,

Özkarataş²,

Özkütük³

et al. 2020

TMCD

View full text Add to dashboard Cite

“…Luetkemyer et al and Parcell et al [ 56 , 57 ] showed in their studies that the performance of Xpert MTB/RIF did not differ between higher- and low-prevalence areas. For HIV-associated TB, Xpert MTB/RIF has lower sensitivity [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid molecular assays for detection of tuberculosis

Eddabra

Benhassou

2018

Pneumonia

View full text Add to dashboard Cite

Tuberculosis (TB) is an infectious disease that remains an important public health problem at the global level. It is one of the main causes of morbidity and mortality, due to the emergence of antibiotic resistant Mycobacterium strains and HIV co-infection. Over the past decade, important progress has been made for better control of the disease. While microscopy and culture continue to be indispensible for laboratory diagnosis of tuberculosis, the range of several molecular diagnostic tests, including the nucleic acid amplification test (NAAT) and whole-genome sequencing (WGS), have expanded tremendously. They are becoming more accessible not only for detection and identification of Mycobacterium tuberculosis complex in clinical specimens, but now extend to diagnosing multi-drug resistant strains. Molecular diagnostic tests provide timely results useful for high-quality patient care, low contamination risk, and ease of performance and speed. This review focuses on the current diagnostic tests in use, including emerging technologies used for detection of tuberculosis in clinical specimens. The sensitivity and specificity of these tests have also been taken into consideration.

show abstract

Three year evaluation of Xpert MTB/RIF in a low prevalence tuberculosis setting: A Scottish perspective

Abstract: Xpert MTB/RIF was rapid and accurate in diagnosing pulmonary TB in a low prevalence area. Rapid results will influence infection prevention and control and treatment measures. The excellent NPV obtained suggests further work should be carried out to assess its role in replacing microscopy.

Cited by 11 publications

References 16 publications

Sputum smear positivity grade and chest X-ray findings in tuberculosis: a cross-sectional study

Sputum smear positivity grade and chest X-ray findings in tuberculosis: a cross-sectional study

Comparison of a Rapid Molecular Method with Conventional Methods for Identification of Mycobacterium tuberculosis complex and Detection of Rifampicin Resistance

Rapid molecular assays for detection of tuberculosis

Contact Info

Product

Resources

About