Three- or four- versus two-drug antiretroviral maintenance regimens for HIV infection

Reconstitution of the immunological defence and Candida albicans infection in oral mucosa of HIV+ patients under HAART

“…In theory, reduction of the antiretroviral drugs included in the medication could be worth, since it implies in lower toxicity and better adherence of the patient to the treatment. However, simplified regimens carry a significant higher risk of resistance and consequent loss of the power of viral suppression 271 . In HIV+ patients the resistance to HAART may be due to the high rate of viral mutations, since the applied drugs have selective effects 226,241 .…”

“…In opposite, very "efficient" medications, there is a high risk of substantial side effects, what may provoke important lack of commitment of the patient with the treatment; what also significantly diminish its efficacy 320,325 . As consensual rule, the therapeutic prescriptions, if working well, must be preserved, unless a change is clinically necessary 271 .…”

Reconstitution of the immunological defence and Candida albicans infection in oral mucosa of HIV+ patients under HAART

“…In theory, reduction of the antiretroviral drugs included in the medication could be worth, since it implies in lower toxicity and better adherence of the patient to the treatment. However, simplified regimens carry a significant higher risk of resistance and consequent loss of the power of viral suppression 271 . In HIV+ patients the resistance to HAART may be due to the high rate of viral mutations, since the applied drugs have selective effects 226,241 .…”

“…In opposite, very "efficient" medications, there is a high risk of substantial side effects, what may provoke important lack of commitment of the patient with the treatment; what also significantly diminish its efficacy 320,325 . As consensual rule, the therapeutic prescriptions, if working well, must be preserved, unless a change is clinically necessary 271 .…”

AIDS Denialism and Public Health Practice

“…The results from use of drugs in combination were so dramatic that the term ''HAART,'' for Highly Active Anti-Retroviral Therapy, was coined. Many systematic reviews have been conducted and updated by the Cochrane Collaboration and other groups, and the data are unanimous regarding efficacy [103][104][105][106][107][108]. In addition, data are now available from the use of ARVs at the program level in African countries and these support the efficacy observed in clinical trials [109][110][111][112][113].…”

Ten years of highly active antiretroviral therapy for HIV infection

“…Most recommended regimens contain at least two NRTIs combined with an ARV from another class. Triple NRTI combinations are inferior to a combination regimen containing at least two classes of ARVs 27 . Current preferred combinations of NRTIs are based largely on efficacy and toxicity and include zidovudine, abacavir or tenofovir plus lamivudine, or emtricitabine plus tenofovir.…”

Reconstitution of the immunological defence and Candida albicans infection in oral mucosa of HIV+ patients under HAART

“…In theory, reduction of the antiretroviral drugs included in the medication could be worth, since it implies in lower toxicity and better adherence of the patient to the treatment. However, simplified regimens carry a significant higher risk of resistance and consequent loss of the power of viral suppression 271 . In HIV+ patients the resistance to HAART may be due to the high rate of viral mutations, since the applied drugs have selective effects 226,241 .…”

“…In opposite, very "efficient" medications, there is a high risk of substantial side effects, what may provoke important lack of commitment of the patient with the treatment; what also significantly diminish its efficacy 320,325 . As consensual rule, the therapeutic prescriptions, if working well, must be preserved, unless a change is clinically necessary 271 .…”

AIDS Denialism and Public Health Practice

“…The results from use of drugs in combination were so dramatic that the term ''HAART,'' for Highly Active Anti-Retroviral Therapy, was coined. Many systematic reviews have been conducted and updated by the Cochrane Collaboration and other groups, and the data are unanimous regarding efficacy [103][104][105][106][107][108]. In addition, data are now available from the use of ARVs at the program level in African countries and these support the efficacy observed in clinical trials [109][110][111][112][113].…”

Ten years of highly active antiretroviral therapy for HIV infection

“…Most recommended regimens contain at least two NRTIs combined with an ARV from another class. Triple NRTI combinations are inferior to a combination regimen containing at least two classes of ARVs 27 . Current preferred combinations of NRTIs are based largely on efficacy and toxicity and include zidovudine, abacavir or tenofovir plus lamivudine, or emtricitabine plus tenofovir.…”

Reconstitution of the immunological defence and Candida albicans infection in oral mucosa of HIV+ patients under HAART

“…In theory, reduction of the antiretroviral drugs included in the medication could be worth, since it implies in lower toxicity and better adherence of the patient to the treatment. However, simplified regimens carry a significant higher risk of resistance and consequent loss of the power of viral suppression 271 . In HIV+ patients the resistance to HAART may be due to the high rate of viral mutations, since the applied drugs have selective effects 226,241 .…”

“…In opposite, very "efficient" medications, there is a high risk of substantial side effects, what may provoke important lack of commitment of the patient with the treatment; what also significantly diminish its efficacy 320,325 . As consensual rule, the therapeutic prescriptions, if working well, must be preserved, unless a change is clinically necessary 271 .…”

AIDS Denialism and Public Health Practice

“…The results from use of drugs in combination were so dramatic that the term ''HAART,'' for Highly Active Anti-Retroviral Therapy, was coined. Many systematic reviews have been conducted and updated by the Cochrane Collaboration and other groups, and the data are unanimous regarding efficacy [103][104][105][106][107][108]. In addition, data are now available from the use of ARVs at the program level in African countries and these support the efficacy observed in clinical trials [109][110][111][112][113].…”

Ten years of highly active antiretroviral therapy for HIV infection

“…Most recommended regimens contain at least two NRTIs combined with an ARV from another class. Triple NRTI combinations are inferior to a combination regimen containing at least two classes of ARVs 27 . Current preferred combinations of NRTIs are based largely on efficacy and toxicity and include zidovudine, abacavir or tenofovir plus lamivudine, or emtricitabine plus tenofovir.…”