Three new highly oxygenated azaphilones from an endophytic fungus Penicillium sp. LZUC-S1

Feng, Zi-Yun; Huang, Pei-Zhi; Jiang, Song-Jie; Shen, Shi-Jin; Chen, Jianjun

doi:10.1016/j.tetlet.2022.154260

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…65 The cold-seepderived fungus Cladosporium cladosporioides 8-1 yields the dimeric naphtha-γ-pyrone, 6-iodofonsecinone A (158), which is assigned the as configuration by comparison of its ECD spectrum with that of (as)-fonsecinone A. Metabolite 158 is quite active against the marine microalga Prorocentrum minimum (IC 50 0.61 μg/mL). 66 The deep-sea cold-seep-derived fungus Talaromyces minioluteus CS-113 from South China Sea sediments affords (+)-5-chloromitorubrinic acid (159). 67 The marine-derived fungus Aspergillus sydowii SCSIO 00305 contains the new mycotoxin 6-methoxy austocystin A (160).…”

Section: ■ Marine Fungimentioning

confidence: 99%

“…This new metabolite shows significant antifungal activity against four pathogenic fungi. 159 This same research team identified the new penimultiones A (332) and B (333) from Penicillium multicolor LZUC-S2, also cultivated from Euphorbia pekinensis and possessing a rare 1,3dioxolane unit. There is no indication that these epimeric acetals are artifacts formed from 331 and formyl acetone.…”

Section: ■ Terrestrial Fungimentioning

confidence: 99%

“…LZUC-S1 isolated from roots of Euphorbia pekinensis produces penicilphilone C ( 331 ) together with two nonchlorinated analogues. This new metabolite shows significant antifungal activity against four pathogenic fungi . This same research team identified the new penimultiones A ( 332 ) and B ( 333 ) from Penicillium multicolor LZUC-S2, also cultivated from Euphorbia pekinensis and possessing a rare 1,3-dioxolane unit.…”

Section: Terrestrial Fungimentioning

confidence: 99%

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A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Gribble

2024

J. Nat. Prod.

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The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discovered�from fewer than 50 in 1968 to a combined 7,958 described examples in three comprehensive reviews. The present survey, which covers the period 2021−2023, brings the number of known natural organohalogens to approximately 8,400. The organization is according to species origin, and coverage includes marine and terrestrial plants, fungi, bacteria, marine sponges, corals, cyanobacteria, tunicates, and other marine organisms.

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Section: ■ Marine Fungimentioning

confidence: 99%

Section: ■ Terrestrial Fungimentioning

confidence: 99%

Section: Terrestrial Fungimentioning

confidence: 99%

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A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Gribble

2024

J. Nat. Prod.

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Endophytic Fungi: A Treasure Trove of Antifungal Metabolites

Saxena,

Dufossé,

Deshmukh

et al. 2024

Microorganisms

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Emerging and reemerging fungal infections are very common in nosocomial and non-nosocomial settings in people having poor immunogenic profiles either due to hematopoietic stem cell transplants or are using immunomodulators to treat chronic inflammatory disease or autoimmune disorders, undergoing cancer therapy or suffering from an immune weakening disease like HIV. The refractory behavior of opportunistic fungi has necessitated the discovery of unconventional antifungals. The emergence of black fungus infection during COVID-19 also triggered the antifungal discovery program. Natural products are one of the alternative sources of antifungals. Endophytic fungi reside and co-evolve within their host plants and, therefore, offer a unique bioresource of novel chemical scaffolds with an array of bioactivities. Hence, immense possibilities exist that these unique chemical scaffolds expressed by the endophytic fungi may play a crucial role in overcoming the burgeoning antimicrobial resistance. These chemical scaffolds so expressed by these endophytic fungi comprise an array of chemical classes beginning from cyclic peptides, sesquiterpenoids, phenols, anthraquinones, coumarins, etc. In this study, endophytic fungi reported in the last six years (2018–2023) have been explored to document the antifungal entities they produce. Approximately 244 antifungal metabolites have been documented in this period by different groups of fungi existing as endophytes. Various aspects of these antifungal metabolites, such as antifungal potential and their chemical structures, have been presented. Yet another unique aspect of this review is the exploration of volatile antifungal compounds produced by these endophytic fungi. Further strategies like epigenetic modifications by chemical as well as biological methods and OSMAC to induce the silent gene clusters have also been presented to generate unprecedented bioactive compounds from these endophytic fungi.

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Three new highly oxygenated azaphilones from an endophytic fungus Penicillium sp. LZUC-S1

Cited by 2 publications

References 22 publications

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds

Endophytic Fungi: A Treasure Trove of Antifungal Metabolites

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