Three-dimensional In Vivo Mapping of Brain Lesions in Humans

Damásio, Hanna; Frank, Randall

doi:10.1001/archneur.1992.00530260037016

Cited by 226 publications

(118 citation statements)

References 3 publications

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“…The three individual data sets were co-registered post hoc with automated image registration (AIR 3.03) to produce a single data set, of enhanced quality, with pixel dimensions of 0.7 mm in plane and 1.5 mm between planes [28]. The MR sequences were reconstructed for each subject in 3-D using Brainvox [13,20]. Extracerebral voxels were edited away manually.…”

Section: Methodsmentioning

confidence: 99%

Neural systems underlying lexical retrieval for sign language

et al. 2003

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Positron emission tomography was used to investigate whether signed languages exhibit the same neural organization for lexical retrieval within classical and non-classical language areas as has been described for spoken English. Ten deaf native American sign language (ASL) signers were shown pictures of unique entities (famous persons) and non-unique entities (animals) and were asked to name each stimulus with an overt signed response. Proper name signed responses to famous people were fingerspelled, and common noun responses to animals were both fingerspelled and signed with native ASL signs. In general, retrieving ASL signs activated neural sites similar to those activated by hearing subjects retrieving English words. Naming famous persons activated the left temporal pole (TP), whereas naming animals (whether fingerspelled or signed) activated left inferotemporal (IT) cortex. The retrieval of fingerspelled and native signs generally engaged the same cortical regions, but fingerspelled signs in addition activated a premotor region, perhaps due to the increased motor planning and sequencing demanded by fingerspelling. Native signs activated portions of the left supramarginal gyrus (SMG), an area previously implicated in the retrieval of phonological features of ASL signs. Overall, the findings indicate that similar neuroanatomical areas are involved in lexical retrieval for both signs and words.

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Section: Methodsmentioning

confidence: 99%

Neural systems underlying lexical retrieval for sign language

et al. 2003

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“…There is relative consensus that the right and/or left fusiform gyri are involved in processes like the recognition of faces [16,17], words [18,19], or numbers [20], color perception [20,21], and within-category object identification [22,23].…”

Section: Introductionmentioning

confidence: 99%

Deficits in face perception in the amnestic form of mild cognitive impairment

Lim

Lee

Barton

et al. 2011

Journal of the Neurological Sciences

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“…All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org functioning (Tranel, in press) and neuroanatomical status (Damasio and Frank, 1992;Frank et al, 1997). To be eligible for enrolment in the current study, the participants had to have focal, stable lesions that involved the VMPC in either the left or right hemisphere.…”

Section: Methods Participantsmentioning

confidence: 99%

“…The VMPC sector corresponds to cells 1-4, numbered in posterior-to-anterior sequence; cell 5 corresponds to the antero-mesial superior sector; cells 6-9 correspond to the lateral orbital sector, again in a posterior-to-anterior sequence; and cell 10 corresponds to an anterior superior dorsolateral sector. For each subject, the percentage involvement (the amount of the cell that is lesioned) in each of these cells was calculated using Brainvox capabilities (Damasio and Frank, 1992;Frank et al, 1997). The lesion data are presented in Fig.…”

Section: Neuroanatomical Data Quantification and Analysismentioning

confidence: 99%

Ventromedial Prefrontal Cortex

2015

Encyclopedia of Psychopharmacology

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We found previously in a lesion study that the right-sided sector of the ventromedial prefrontal cortices (VMPCs) was critical for social/emotional functioning and decision-making, whereas the left side appeared to be less important. It so happened that all but one of the subjects in that study were men, and the one woman did not fit the pattern very well. This prompted a follow-up investigation, in which we explored the following question: Does gender play a role in the development of defects in social conduct, emotional functioning and decision-making, following unilateral VMPC damage? We culled from our Patient Registry same-sex pairs of men or women patients who had comparable unilateral VMPC damage in either the left or right hemisphere. Two male pairs and one female pair were formed, and we included two additional women with unilateral right VMPC damage (8 patients in all). The domains of measurement covered social conduct, emotional processing and personality, and decision-making. We found a systematic effect of gender on the pattern of left-right asymmetry in VMPC. In men, there were severe defects following unilateral right VMPC damage, but not following left-sided damage. In women, there were defects following unilateral left VMPC damage; following right-sided damage, however, defects were mild or absent. The findings suggest that men and women may use different strategies to solve similar problems-e.g. men may use a more holistic, gestalt-type strategy, and women may use a more analytic, verbally-mediated strategy. Such differences could reflect asymmetric, gender-related differences in the neurobiology of left and right VMPC sectors.

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Three-dimensional In Vivo Mapping of Brain Lesions in Humans

Cited by 226 publications

References 3 publications

Neural systems underlying lexical retrieval for sign language

Neural systems underlying lexical retrieval for sign language

Deficits in face perception in the amnestic form of mild cognitive impairment

Ventromedial Prefrontal Cortex

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