Three cases of brain metastasis from castration‐resistant prostate cancer

Abstract

Brain metastasis from prostate cancer may be becoming more common and may be associated with occurrence of diffuse systemic metastases. K E Y W O R D Sbrain metastasis, castration-resistant prostate cancer, whole-brain radiotherapy

The Clinical, Diagnostic, Therapeutic, and Prognostic Characteristics of Brain Metastases in Prostate Cancer: A Systematic Review

“…As illustrated in the results, the first line imaging modality to detect BMs in PCa is a noncontrast CT scan which identifies lethal neurological conditions including hemorrhage, hydrocephaly, or massive compressive lesions [ 9 , 29 , 30 , 38 , 41 , 44 , 87 ]. Before using MRI as a diagnostic tool for detecting CNS metastases, imaging modalities lack the sensitivity to identify multiple intraparenchymal metastatic lesions.…”

“…In some studies, it is recommended that dexamethasone can be prescribed to reduce the incidence of acute radiation toxicity if patients were asymptomatic and showed signs of cerebral edema on radiographic imaging before the radiotherapy [ 110 ]. In one study, mannitol, furosemide, and dexamethasone as supportive therapy were used to reduce intracerebral pressure, and have since started as major therapies for the treatment of BMs such as WBRT [ 29 ].…”

“…Also, during the follow-up of three PCa patients with brain involvement, surgical treatment was considered as the initial treatment, but the systemic status of the cancer was out of control and the number of metastases was more than 5, and SRS has not been considered because it cannot affect the whole disease, so all three patients were treated with WBRT only. The WBRT reduced the symptoms of BMs in all three patients, however, its effect on the prognosis of patients was not promising [ 29 , 113 ]. Because elderly patients do not often tolerate standard radiotherapy treatments, personalized treatments can be a good option in managing elderly patients [ 29 , 113 ].…”

“…The WBRT reduced the symptoms of BMs in all three patients, however, its effect on the prognosis of patients was not promising [ 29 , 113 ]. Because elderly patients do not often tolerate standard radiotherapy treatments, personalized treatments can be a good option in managing elderly patients [ 29 , 113 ].…”

Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine

“…Since recent drug trials show improved overall survival for castration-resistant prostate cancer, it seems likely that cases of previously unrecognized dural metastases may become more clinically relevant. Cases of dural and parenchimal metastases from prostate cancer have been reported in the literature [5][6][7][8][9], but data on dural metastases with a bilateral "en plaque" morphological pattern are more limited [1,10]. To the best of our knowledge, no reports on 18 F-FCH appearance in dural metastases from prostate cancer are present in the English scientific literature.…”