Three cases of bone metastases in patients with gastrointestinal stromal tumors

Scioscio, Valerio Di; Greco, Laura; Pallotti, Maria Caterina; Pantaleo, Maria Abbondanza; Maleddu, Alessandra; Nannini, Margherita; Bazzocchi, Alberto; Battista, Monica Di; Mandrioli, Anna; Lolli, Cristian; Saponara, Maristella; Garzillo, Giorgio; Biasco, Guido; Zompatori, Maurizio

doi:10.4081/rt.2011.e17

Cited by 30 publications

(42 citation statements)

References 17 publications

(15 reference statements)

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“…They tend to stay in the abdominal cavity even in very advanced stage13). Only a few papers have reported bone metastases of GIST1,5,6,8,10), and the most frequent site of bone metastases re ported were spine and pelvis5,6). Skull metastasis is even rarer.…”

Section: Discussionmentioning

confidence: 99%

Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery

Park

Chung

Yoo

et al. 2017

J Korean Neurosurg Soc

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Gastrointestinal stromal tumors (GISTs) are rare, but are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common sites of metastasis are liver and peritoneum, while bone metastasis is rare. We report on a patient with skull metastasis after seven years of treatment with imatinib for metastatic GIST. She underwent metastasectomy consisting of craniectomy with excision of the mass, and cranioplasty and continued treatment with imatinib and sunitinib, without evidence of cranial recurrence. She died of pneumonia sepsis one year after metastasectomy. Skull metastasis of GIST is a very rare presentation, and an aggressive multidisciplinary approach should be considered whenever possible.

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Section: Discussionmentioning

confidence: 99%

Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery

Park

Chung

Yoo

et al. 2017

J Korean Neurosurg Soc

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“…In addition, it is also rare for GIST-derived bone metastasis to be detected in cases in which the primary tumor is of unknown origin [11]. On radiological images, GIST-derived bone metastasis presents as an osteolytic lesion [5] (Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that it is rare for bone metastasis to be detected as the first metastasis (or as a solitary lesion) from GIST [5]. In addition, it is also rare for GIST-derived bone metastasis to be detected in cases in which the primary tumor is of unknown origin [11].…”

Section: Discussionmentioning

confidence: 99%

“…The frequency of bone metastasis from GIST has been reported to range from 3.2 to 6.0% [2, 3]. GIST-derived bone metastases are osteolytic lesions and occur most commonly in the spine and pelvis [2, 4, 5]. Swift treatment is needed for GIST-derived bone metastases in order to prevent pathological fractures, and many cases require emergent treatment [6].…”

Section: Introductionmentioning

confidence: 99%

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Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis

et al. 2018

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Objective: Procedures for diagnosing bone tumors should be rapid and minimally invasive. Thus, cytological examinations are more useful for such purposes than histological examinations. In order to identify cytomorphological findings that could be used to diagnose bone metastasis from gastrointestinal stromal tumors (GIST), previous cases were reviewed. Study Design: Cytological samples of 7 lesions from 4 patients with GIST-derived bone metastasis, which were obtained from 2001 to 2017 at the JFCR Cancer Institute Hospital, were reviewed. Results: The metastasis of GIST to the bone was clinically suspected before the cytological and histological examinations in all cases since they all involved other metastatic lesion(s), and characteristic osteolytic lesions were detected on radiological images. Although various cell shapes were encountered, spindle cell proliferation was seen in all cytological samples. No pleomorphism was apparent. Characteristic nuclear findings were observed. All of the cases could be diagnosed as GIST-derived bone metastasis. Conclusion: GIST-derived bone metastasis can be diagnosed by examining cytological samples.

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“…Finally, RT can be used for palliation of local symptoms. In the setting of locally progressive and/or metastatic GISTs, short courses of RT have been shown to be effective for tumor control and symptom management, with low rates of toxicity 43–46…”

Section: The Rationale For Radiation Therapy (Rt)mentioning

confidence: 99%

Considering the role of radiation therapy for gastrointestinal stromal tumor

Corbin¹,

Kindler²,

Liauw³

2014

OTT

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Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising in the gastrointestinal tract. Over the last decade, the management and prognosis of GISTs has changed dramatically with molecular characterization of the c-kit mutation and the adoption of targeted systemic therapy. Currently, the standard of care for resectable tumors is surgery, followed by adjuvant imatinib for tumors at high risk for recurrence. Inoperable or metastatic tumors are treated primarily with imatinib. Despite excellent initial response rates, resistance to targeted therapy has emerged as a common clinical problem, with relatively few therapeutic solutions. While the treatment of GISTs does not commonly include radiotherapy, radiation therapy could be a valuable contributing modality. Several case reports indicate that radiation can control locally progressive, drug-resistant disease. Further study is necessary to define whether radiation could potentially prevent or delay the onset of drug resistance, or improve outcomes when given in combination with imatinib.

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Three cases of bone metastases in patients with gastrointestinal stromal tumors

Cited by 30 publications

References 17 publications

Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery

Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery

Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis

Considering the role of radiation therapy for gastrointestinal stromal tumor

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