Threatening biomarkers in lupus pregnancy: Biochemistry and genetic challenges

Mowla, Karim; Rajaei, Elham; Jalali, Mohammad Taha; Zayeri, Zeinab Deris

doi:10.1007/s11515-017-1477-8

Cited by 6 publications

(2 citation statements)

References 65 publications

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“…It is a significant reproductive problem affecting approximately 1–2% of women who try to conceive . Although multiple factors like infection, genetics, hormones, uterine/ovary anatomy and antiphospholipid syndrome have been linked to recurrent spontaneous abortion, the causes of 25–50% of RSM occurrence remain unknown . Angiogenesis, cell proliferation and cell differentiation are considered as essential factors in successful pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Sajjadi

Ghandil

Shahbazian

et al. 2020

J of Obstet and Gynaecol

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Aim Idiopathic recurrent spontaneous miscarriage (IRSM) is one of the pregnancy outcomes that affects 1–2% of women trying to conceive. Specific genotype or aberrant expression of vascular endothelial growth factor A (VEGFA) and connexin 43 (Cx43) as two important genes for embryonic development are deemed to increase the risk of IRSM. Methods To investigate any possible association of VEGFA polymorphisms and aberrant expression of Cx43 and VEGFA with IRSM, we carried out a case–control study including embryo chorionic villus tissues of 100 pregnant women with IRSM and 100 embryo chorionic villus tissues of healthy pregnant women without history of miscarriage. Restriction fragment length polymorphism was used for genotyping of rs699947 (−2578C/A) and rs2010963 (−634G/C) polymorphisms in VEGFA. Besides, quantitative real‐time PCR was performed for VEGFA and Cx43 expression analysis. Results The results showed that the frequency of −634G/C and C/C genotypes was significantly higher in aborted fetuses (P = 0.001 and P < 0.001, respectively) compared to the control group's. However, the frequency of −2578C/A genotypes was not significantly different between the cases and controls. Moreover, a significant higher expression of VEGF (P = 0.0005) and Cx43 (P = 0.0011) was observed in chorionic villus tissues of women with IRSM. Conclusion The finding demonstrated that IRSM frequency may depend on GC and CC genotypes of rs2010963 VEGF polymorphism and expression level of VEGF and Cx43 in IRSM patients was increased.

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Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Sajjadi

Ghandil

Shahbazian

et al. 2020

J of Obstet and Gynaecol

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“…Several biomarkers, such as antiphospholipid antibodies (APLs), anti-dsDNA antibody (complement level, mainly C3 and C4), and a cluster of differentiation (CD) markers are used in the diagnosis of this disease. However, the challenge is to define an appropriate profile in the diagnosis of SLE (Mowla, Rajaei, Jalali, & Zayeri, 2018). The diagnosis of SLE is always a challenge for physicians, and several diagnostic criteria and profiles have been developed to improve the management and facilitate the inclusion criteria of patients.…”

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confidence: 99%

Flip‐flops of natural killer cells in autoimmune diseases versus cancers: Immunologic axis

Shahrabi

Zayeri

Ansari

et al. 2019

Journal Cellular Physiology

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Natural killer (NK) cells play an essential role in the immune response to infections, inflammations, and malignancies. Recent studies suggest that NK cell surface receptors and cytokines are the key points of the disease development and protection. We hypothesized that the interactions between NK cell receptors and targeted cells construct an eventual niche, and this niche has an eventual profile in various autoimmune diseases and cancers. The NK cells preactivated with cytokines, such as interleukin‐2 (IL‐2), IL‐12, IL‐15, and IL‐18 can have higher cytotoxicity; however, the toxic side effect of IL‐2 should be considered. The vicissitudes of NK cell profile and its receptors obey the environmental communications and cell interactions. Our vision around the NK cells as an immune axis remained dual, and we still cannot judge the immune responses based on the NK cell flip‐flop. A design of eventual niche to monitor the NK cell and targeted cell interaction is needed to strengthen our ability in diagnosis and treatment approaches based on the NK cells. Here, we have reviewed the shifts in the NK cells and their surface receptors in autoimmune diseases, solid tumors, and leukemia, and also discussed the effective chemokines that affect NK cell activation and proliferation. The main aim of this review is to present a broader vision of the NK cell changes in autoimmune disease and cancers.

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Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region

Chen

et al. 2019

Clin Rheumatol

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Threatening biomarkers in lupus pregnancy: Biochemistry and genetic challenges

Cited by 6 publications

References 65 publications

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Flip‐flops of natural killer cells in autoimmune diseases versus cancers: Immunologic axis

Ankylosing spondylitis is associated with aberrant DNA methylation of IFN regulatory factor 8 gene promoter region

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