Subsidizing cross-border regions is a method to close the gap between citizens and the European Union. This analysis of PAMINA, a crossborder region in the Rhine Valley near Karlsruhe, discusses some of the difficulties of this policy. There are structural mismatches between the scales of different cross-border relations. These vertical mismatches are linked to the differences in the horizontal logics of economic and administrative cross-border relations. Especially cross-border commuting, made possible by European economic integration, has improved the daily life of many inhabitants of this region. Paradoxically this regional success of European economic integration is disconnected from the EU funded cross-border region. They not only relate to different scales, but the same spatial asymmetry generating this cross-border behaviour hinders administrative cross-border cooperation in PAMINA.