Thioureas and their cyclized derivatives: Synthesis, conformational analysis and antimicrobial evaluation

Synthesis, Characterization and Biological Evaluation of Novel Thiourea Derivatives

“…The amyloid cascade hypothesis 1 suggests that the consequent accumulation of Aβ peptides mediates the pathogenesis of AD through synaptic injury, gliosis, and NFTs. Amyloid beta loads are associated positively with clinical cognitive severity and faster cognitive decline in people with subjective memory impairment (SMI), 2 mild cognitive impairment (MCI), 3 and early AD. 4 Mild cognitive impairment patients with amyloid-positive deposition have a significantly greater risk of progression to dementia compared with people with amyloid-negative deposition, 5 and faster converters have higher Aβ load than slower converters.…”

“…Thiourea functional groups have numerous pharmacological activities such as antidiabetic, antibacterial, antifungal, antiviral, anticancer, anticonvulsant, antidiabetic (1)(2)(3). Thioureas play an important role in the regulation of various pharmacological activities by increasing potency and selectivity or by modulating of physicochemical properties.…”

A novel colorimetric chemosensor for selective and highly sensitive determination of thiourea: An approach toward a molecular keypad lock

“…Hg 2+ can reason earnest health issues such as anemia, brain, peripheral and central nervous system, liver, and kidney failure, diabetes, and heart damage, therefore, it is very significant to measure trace contents of Hg 2+ in contaminated products. [8][9][10][11] On the other hand, thiourea and its derivatives are substantial neutral organic compounds that have immense utilization in various fields such as vulcanizing of rubber, [12] gold mining, [13] inhibitors in corrosion, [14] ripening agents, fungicides and fertilizers, [15,16] antimicrobials, [17] and antifungals. [18,19] Thiourea is also used as a spectrophotometric reagent for the measurement of metals in analytical chemistry.…”

“…On the other hand, thiourea and its derivatives are substantial neutral organic compounds that have immense utilization in various fields such as vulcanizing of rubber, [ 12 ] gold mining, [ 13 ] inhibitors in corrosion, [ 14 ] ripening agents, fungicides and fertilizers, [ 15,16 ] antimicrobials, [ 17 ] and antifungals. [ 18,19 ] Thiourea is also used as a spectrophotometric reagent for the measurement of metals in analytical chemistry.…”

An Acyclic Diaminocarbene Complex of Platinum Formed by Desulfurization of 1,3‐Bis(3‐methylpyridin‐2‐yl)thiourea

“…The suggested mechanism of C=S cleavage involves an iron carbene complex which was characterized by X-ray spectroscopy. [39,40] Thiourea compounds are highly versatile organosulfur materials with diverse uses ranging from pharmacological applications, including anion transport in biological systems, [41][42][43][44] to organocatalysis of important reactions such as Diels-Alder cycloadditions and Friedel-Crafts alkylations, mainly due to their capacity for multiple hydrogen bonding. [44] In addition, the coordination chemistry of thiourea and of its substituted derivatives has attracted attention owing to the availability of different coordination sites in these molecules, coupled with diverse biological activities.…”