Thiols in blood

Turell, Lucía; Möller, Matías N.; Orrico, Florencia; Randall, Lía M.; Steglich, Martina; Villar, Sebastián F.; Denicola, Ana; Thomson, Leonor

doi:10.1016/b978-0-323-90219-9.00025-x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Laura Orian1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 251 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25,52 Furthermore, cysteine (Cys) and cystine can be found in the blood and tissues of the human body. 53 Other important lowmolecular mass thiols (LMM-SH) include metabolite intermediates of Met (e.g., homocysteine), glutathione (GSH or GSSG), co-enzyme A (CoA) and lipoic acid (Fig. 2).…”

Section: Laura Orianmentioning

confidence: 99%

Organic selenocompounds: are they the panacea for human illnesses?

Rocha

Nogara²,

Pereira³

et al. 2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

Section: Laura Orianmentioning

confidence: 99%

Organic selenocompounds: are they the panacea for human illnesses?

Rocha

Nogara²,

Pereira³

et al. 2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

Oxidants and Antioxidants in the Redox Biochemistry of Human Red Blood Cells

et al. 2022

View full text Add to dashboard Cite

Red blood cells (RBCs) are exposed to both external and internal sources of oxidants that challenge their integrity and compromise their physiological function and supply of oxygen to tissues. Autoxidation of oxyhemoglobin is the main source of endogenous RBC oxidant production, yielding superoxide radical and then hydrogen peroxide. In addition, potent oxidants from other blood cells and the surrounding endothelium can reach the RBCs. Abundant and efficient enzymatic systems and low molecular weight antioxidants prevent most of the damage to the RBCs and also position the RBCs as a sink of vascular oxidants that allow the body to maintain a healthy circulatory system. Among the antioxidant enzymes, the thiol-dependent peroxidase peroxiredoxin 2, highly abundant in RBCs, is essential to keep the redox balance. A great part of the RBC antioxidant activity is supported by an active glucose metabolism that provides reducing power in the form of NADPH via the pentose phosphate pathway. There are several RBC defects and situations that generate oxidative stress conditions where the defense mechanisms are overwhelmed, and these include glucose-6-phosphate dehydrogenase deficiencies (favism), hemoglobinopathies like sickle cell disease and thalassemia, as well as packed RBCs for transfusion that suffer from storage lesions. These oxidative stress-associated pathologies of the RBCs underline the relevance of redox balance in these anucleated cells that lack a mechanism of DNA-inducible antioxidant response and rely on a complex and robust network of antioxidant systems.

show abstract

Thiols in blood

Cited by 2 publications

References 251 publications

Organic selenocompounds: are they the panacea for human illnesses?

Organic selenocompounds: are they the panacea for human illnesses?

Oxidants and Antioxidants in the Redox Biochemistry of Human Red Blood Cells

Contact Info

Product

Resources

About