Thiocladospolide E and cladospamide A, novel 12-membered macrolide and macrolide lactam from mangrove endophytic fungus Cladosporium sp. SCNU-F0001

Huang, Chuixiu; Chen, Tao; Yan, Zhangyuan; Guo, Huixian; Hou, Xiaobei; Jiang, Lasheng; Long, Yuhua

doi:10.1016/j.fitote.2019.104246

Cited by 20 publications

(15 citation statements)

References 16 publications

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“…50 µg/mL towards Bugula neritina and Balanus amphitrite larvae in the settlement inhibition assays [60] (Figure 6). They inhibited B. neritina settlement (EC 50 70.43 and >200 µg/mL, respectively) and B. amphitrite settlement (EC 50 68.57 and 37.82 µg/mL, respectively). Furthermore, 32 and 33 obviously prohibited L. hongkongensis growth (IZDs 8 mm and MICs 200 and 200 µg/mL, respectively), compared to streptomycin (MIC 250 µg/mL).…”

Section: Diketopiperazinesmentioning

confidence: 97%

“…100 µg/mL) towards S. aureus, B. subtilis, E. coli, Salmonella ATCC 14028, and P. aeruginosa. Unfortunately, it exhibited no noticeable activity [70].…”

Section: Alkaloidsmentioning

confidence: 99%

“…100 µg/mL) towards S. aureus, B. subtilis, E. coli, Salmonella ATCC 14028, and P. aeruginosa. Unfortunately, none of them exhibited noticeable activity [70]. Cao et al purified 12-membered macrolides 89 and 117-120 from a gorgonian-derived Cladosporium sp.…”

Section: Macrolidesmentioning

confidence: 99%

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Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities

Mohamed

Ibrahim

2021

Marine Drugs

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The marine environment is an underexplored treasure that hosts huge biodiversity of microorganisms. Marine-derived fungi are a rich source of novel metabolites with unique structural features, bioactivities, and biotechnological applications. Marine-associated Cladosporium species have attracted considerable interest because of their ability to produce a wide array of metabolites, including alkaloids, macrolides, diketopiperazines, pyrones, tetralones, sterols, phenolics, terpenes, lactones, and tetramic acid derivatives that possess versatile bioactivities. Moreover, they produce diverse enzymes with biotechnological and industrial relevance. This review gives an overview on the Cladosporium species derived from marine habitats, including their metabolites and bioactivities, as well as the industrial and biotechnological potential of these species. In the current review, 286 compounds have been listed based on the reported data from 1998 until July 2021. Moreover, more than 175 references have been cited.

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Section: Diketopiperazinesmentioning

confidence: 97%

“…100 µg/mL) towards S. aureus, B. subtilis, E. coli, Salmonella ATCC 14028, and P. aeruginosa. Unfortunately, it exhibited no noticeable activity [70].…”

Section: Alkaloidsmentioning

confidence: 99%

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Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities

Mohamed

Ibrahim

2021

Marine Drugs

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“…The investigation of metabolites produced by the mangrove endophytic Cladosporium sp. led to the isolation of new compounds called thiocladospolides A–E ( 103 – 107 , Figure 19 ) and the macrodiolide lactam derived from ornithine, called cladospamide A ( 81 ), together with the known cladospolide B ( 83 ) [ 33 , 91 ]. This latter compound was previously isolated and identified during a screening for new plant growth regulators produced by C. cladosporioides , along with its isomer cladospolide A ( 82 ) [ 114 , 115 , 116 ].…”

Section: Fifty Years Of Metabolomic Studies In Cladosporiummentioning

confidence: 99%

The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds

2021

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Fungi are renowned as one of the most fruitful sources of chemodiversity and for their ubiquitous occurrence. Among the many taxonomic groupings considered for the implications deriving from their biosynthetic aptitudes, the genus Cladosporium stands out as one of the most common in indoor environments. A better understanding of the impact of these fungi on human health and activities is clearly based on the improvement of our knowledge of the structural aspects and biological properties of their secondary metabolites, which are reviewed in the present paper.

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“…The genus Cladosporium (Cladosporiaceae) is one of the largest genera of dematiaceous hyphomycetes ( Bensch et al, 2015 ). Many novel bioactive natural products were isolated from Cladosporium fungus, such as polyketides ( Zhang et al, 2019 ; Zhu et al, 2018 ), macrolides ( Huang et al, 2019 ), perylenequinones ( Zhang et al, 2020 ), and indole alkaloids ( Peng et al, 2013 ), which exhibited antimicrobial ( Zhang et al, 2019 ), cytotoxic ( Zhu et al, 2018 ), antiviral ( Peng et al, 2013 ), and quorum-sensing inhibitory activities ( Zhang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

Guo²,

Cai

et al. 2021

Front. Chem.

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Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new β-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-β-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh2(OCOCF3)4-induced ECD experiments, and Marfey’s method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 ± 0.08 μM. Moreover, compounds 1 and 5 exhibited inhibitory activity against α-glycosidase with IC50 values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.

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Thiocladospolide E and cladospamide A, novel 12-membered macrolide and macrolide lactam from mangrove endophytic fungus Cladosporium sp. SCNU-F0001

Cited by 20 publications

References 16 publications

Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities

Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities

The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds

Metabolites From the Mangrove-Derived Fungus Cladosporium sp. HNWSW-1

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