Thin Pliable Plastic Films in Topical Dermatologic Therapy

Sulzberger, Marion B.

doi:10.1001/archderm.1961.01580180143024

Cited by 99 publications

(9 citation statements)

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“…Hydrocortisone displayed increased corticoid activity under occlusion for treatment of psoriasis (Sulzberger and Witten, 1961 (Feldmann and Maibach, 1965). The experimental group used plastic wrap as the occlusive agent, and had signifi cantly higher absorption of hydrocortisone than the normal, unoccluded skin.…”

Section: Percutaneous Penetrationmentioning

confidence: 99%

Toxicologic implications of cutaneous barriers: a molecular, cellular, and anatomical overview

Karan

Alikhan

Maibach

2009

J of Applied Toxicology

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The skin barrier is a complex system of chemical, biological and physical processes that together regulate the admission and expulsion of foreign agents in contact with the skin. The eggresive movement of the stratum corneum (SC) is often a measure of its integrity, and transepidermal water loss has typically been a gold standard. However, the skin barrier has several barrier systems, such as ion flux, O(2), CO(2) and pH, which can give an informative and sometimes more sensitive measure of the SC condition. Furthermore, the penetrative interactions with the barrier have focused around occlusive methods to promote drug delivery, the interactions of topically applied drugs with the barrier and the presence of environmental agents that can harm the barrier. However, the nature of penetrative barrier interactions must also be elucidated on a microscopic level. The variable nature of barrier function is demonstrated when comparing the skin properties of neonates and adults. In addition, new biochemical methods have used keratin metrics to improve diagnostic efficacy and barrier integrity analysis. This review addresses the aforementioned aspects of the skin barriers that require further study to help discern the complexity of this essential organ as it relates to dermatotoxicology and dermatopharmacology.

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Section: Percutaneous Penetrationmentioning

confidence: 99%

Toxicologic implications of cutaneous barriers: a molecular, cellular, and anatomical overview

Karan

Alikhan

Maibach

2009

J of Applied Toxicology

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“…Maximum hydration results in a 10-fold increase in penetration. This correlates with the huge increase in biologic activity of topical steroids seen with occlusive wrap in vasoconstriction assays [6] and clinical observations [7], Table IV illustrates a very important point in interpretation of the difference in biologic activity of analogs of steroids such as fluocinolone alcohol versus fluocinolone acetonide, betamethasone alcohol versus betamethasone valerate and fluocinolone acetonide versus fluocinolone acetonide 21-acetate. The biologic activity of betamethasone 17-valerate is 100 times that of betamethasone alcohol by vasoconstrictor assay [8] and superior in clinical activity in skin diseases.…”

mentioning

confidence: 72%

Penetration of Drugs through the Skin

Stoughton¹

1976

Dermatology

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Various methods for measuring percutaneous absorption are discussed with particular reference to glucocorticosteroids. Increasing concentrations of steroids in a given formulation will yield a decreasing percent of amount penetrating and a corresponding proportionate decrease in biologic activity. The formulation can shift the relationships of concentration to penetration and to biologic activity. The use of bioassay methods to detect penetration of antibiotics has been applied to find an active topical antibiotic for treatment of acne vulgaris.

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“…Maibach [4] has shown that hydrocortisone is absorbed in tenfold greater amounts under plastic occlusion when compared to unoccluded. Sultzberger and Witten [6] showed that triamcinolone acetonide ointment under plastic occlusion was clinically as effective in obstinate psoriasis as an intralesional injection of the steroid. They attributed the enhanced activity to better contact between the ointment and the skin, more accurate localization of the ointment and increased percutaneous absorption as a result of epidermal maceration.…”

Section: Aterials and Methodsmentioning

confidence: 99%