Thin-Layer Chromatography of Analgesics-An Update

Elder, John W.

doi:10.1021/ed072p1049

Cited by 11 publications

(11 citation statements)

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“…For problem solving exercises, the think-pair-share model is employed to encourage active learning and collaboration. Periodic discussions are held that focus on Scientific American articles pertinent to class topics, ranging from the spread of antibiotic resistance, [13] to the molecular basis of addiction, [14] 31 to rational drug design. [15] For laboratory activities, students work in pairs for experiments, but they turn in individual laboratory worksheets and reports.…”

Section: Course Designmentioning

confidence: 99%

“…Therefore, articles focused on the molecular basis of addiction and approaches to fighting addiction are discussed. [14, 22] …”

Section: Course Contentmentioning

confidence: 99%

“…In parallel to learning about concepts in class, students perform weekly inquiry-based laboratories that are designed to reinforce their molecular worldview. For example, students employ molecular models to explore what molecules look like in three dimensions, perform thin layer chromatography to evaluate how molecules can be separated from one another [14], and evaluate how a tea alters taste perception via a molecule that binds and blocks a taste receptor [19]. Later in the semester, students embark upon a multi-week "research-like" project laboratory, in which they design and implement their own experiments to search for antimicrobials.…”

Section: Course Descriptionmentioning

confidence: 99%

“…These concepts in turn segue into how these properties can be taken advantage to separate molecules from one another via extraction and chromatography. In a corresponding laboratory activity, students perform extractions and thin layer chromatography analyses to ascertain what components are present within unknown over-the-counter analgesics (see Supporting Information) [13,14].…”

Section: Weeks 2-4: Building a Molecular Worldviewmentioning

confidence: 99%

“…In addition to offering a unifying theme for covering chemistry and biochemistry concepts in the classroom, the drug discovery theme is rife with possibilities for inquirybased laboratories. Previously described laboratory-based activities, including molecular modeling of pharmaceuticals [11,12], thin-layer chromatography-based analysis of analgesics [13,14], chemical synthesis of aspirin [15], screening of molecules for antimicrobial activity [16,17], and computer-aided drug design [18], fit seamlessly under the drug discovery umbrella. Further, drug discovery is a multidisciplinary topic that has connections to the history of scientific thought, the sociology of access to healthcare, the neuroscience of drug addiction, the public health impacts of antibiotic resistance, the economics of drug pricing, the laws behind patent protection, and the government oversight of pharmaceuticals, on top of the underpinning chemistry and biochemistry concepts.…”

mentioning

confidence: 99%

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Design of a drug discovery course for non‐science majors

Dube

2018

Biochem Molecular Bio Educ

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"Drug Discovery" is a 13-week lecture and laboratory-based course that was developed to introduce non-science majors to foundational chemistry and biochemistry concepts as they relate to the unifying theme of drug discovery. The first part of this course strives to build students' understanding of molecules, their properties, the differences that enable them to be separated from one another, and their abilities to bind to biological receptors and elicit physiological effects. After building students' molecular worldview, the course then focuses on four classes of drugs: antimicrobials, drugs that affect the mind, steroid-based drugs, and anti-cancer drugs. During each of these modules, an emphasis is placed on how understanding the basis of disease and molecular-level interactions empowers us to identify novel medicinal compounds. Periodic in class discussions based on articles pertinent to class topics ranging from the spread of antibiotic resistance, to the molecular basis of addiction, to rational drug design, are held to enable students to relate course material to pressing problems of national and daily concern. In addition to class time, weekly inquiry-based laboratories allow students to critically analyze data related to course concepts, and later in the semester give students an opportunity to design and implement their own experiments to screen for antimicrobial activity. This course provides students with an understanding of the importance of chemistry and biochemistry to human health while emphasizing the process, strategies, and challenges related to drug discovery. © 2018 by The International Union of Biochemistry and Molecular Biology, 46:327-335, 2018.

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Section: Course Designmentioning

confidence: 99%

“…Therefore, articles focused on the molecular basis of addiction and approaches to fighting addiction are discussed. [14, 22] …”

Section: Course Contentmentioning

confidence: 99%

Section: Course Descriptionmentioning

confidence: 99%

Section: Weeks 2-4: Building a Molecular Worldviewmentioning

confidence: 99%

mentioning

confidence: 99%

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Design of a drug discovery course for non‐science majors

Dube

2018

Biochem Molecular Bio Educ

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Quantitative analysis of analgoantipyretics in dosage form using planar chromatography

Franeta

Agbaba

Erić

et al. 2001

Journal of Pharmaceutical and Biomedical Analysis

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Planar Chromatography

Sherma

1998

Anal. Chem.

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GENERAL CONSIDERATIONSHistory, Books, Reviews, and Student Experiments. The discovery of TLC by Nikolai Izmailov and Maria Schreiber in 1938 was reviewed (A1). The first TLC book arranged by discipline contained chapters covering applications in bacteriology, plant sciences, parasitology, entomology, clinical chemistry, environmental analysis, food analysis, forensic toxicology, pharmaceutical analysis, veterinary toxicology, and analysis of skin secretions in vertebrates (A2). A book on TLC in German contained a random assortment of chapters on techniques and applications, including uses in a clinical laboratory, properties of different layers, determination of the pesticide propham, optimization of mobile phases, video densitometry, determination of PAHs in water, determination of water solubility of higher fatty acids, visualizing reagents for higher fatty acids, pharmaceutical analysis, on-line coupling of AMD and HPLC for determination of plant protection agents in water, and enzymic detection of pollutants (A3). A TLC atlas for plant drug analysis was published (A4). The fourth edition of Thin Layer Chromatography-Techniques and Applications by B. Fried and J. Sherma is in production and will be published by Marcel Dekker, Inc. in late 1998 or early 1999.Review articles were published on the following topics: instruments and techniques (A5), determination of organic compounds (A6), food analysis (A7), environmental analysis (A8), and general progress and development (A9). Other pertinent reviews are cited in the sections below.

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Thin-Layer Chromatography of Analgesics-An Update

Abstract: Acetominaphen, aspirin, caffeine, ibuprofen, and naproxensodium are determined by thin-layer chromatography.

Cited by 11 publications

References 0 publications

Design of a drug discovery course for non‐science majors

Design of a drug discovery course for non‐science majors

Quantitative analysis of analgoantipyretics in dosage form using planar chromatography

Planar Chromatography

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