Thin-film microsystem applicable in (bio)chemical sensors

Interdigital sensors and transducers

“…Lipid bilayers, which constitute the basic structure of all biological membranes, have been used to monitor pH changes in surrounding fluids [90]. A thin layer of polypyrrole coating was found to change its conductivity with the concentration of penicillin that affected the pH response of penicillinase membrane [78].…”

Supported Bilayer Lipid Membranes as Ion and Molecular Probes

“…As demonstrated by us and others 11,12,26 , the solid supported BLM system (s-BLM) not only possesses the advantages of a conventional BLM structure but additionally gains the new important properties such as (a) the long-term stability, (b) a highly ordered, yet very dynamic liquid-like structure, (c) two asymmetric interfaces, and (d) this type of probe is destined for microelectronics fabrication. On this last mentioned property, we have extended the experiment to the interdigitated structures (IDS).…”

“…To test our concept, we incorporated a number of quinonoid compounds (chloranils) into s-BLMs and found that, indeed, s-BLMs containing either TCoBQ (tetrachloroo-benzoquinone) or TCpBQ (tetrachloro-p-benzoquinone) responded to pH changes with a nearly theoretical slope (55±3 mV). 11,13,15 This pH-sensitive s-BLM offers prospects for ligand-selective probe development using microelectronics technologies (see below). Interdigitated structure-based sensors.…”

“…4) as follow: (11) In concluding this analysis, the only parameters that need to be acquired directly for a recorded voltammogram of s-BLM are D, y 1 , ∆y and 2h. From the relationship described in Eqs.…”

“…Several investigators have reported conductometric urea sensors using interdigitated electrodes. 2,11,15 Using interdigitated electrodes (IDS) of our own design 2,11 , urease was embedded on the surface of an IDS with Pt "fingers" of 25 on each lead in a measuring window 0.3×0.3 mm. We have also experimented with IDS of a circular design (6 mm diameter) with 7 and 8 fingers for each electrode, with similar results.…”