Thickness alterations of retinal nerve fiber layer in children with sleep-disordered breathing due to adenotonsillar hypertrophy

Cinici, Emine; Tatar, Arzu

doi:10.1016/j.ijporl.2015.05.017

Cited by 13 publications

(25 citation statements)

References 38 publications

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“…43 It has also been indicated that RGCs are more sensitive to ischemia than the more distal retinal cells. 44,45 Retinal hypoxia leads to increase in some mediators including vascular endothelial growth factor, nitric oxide, glutamate, inflammatory cytokines, and reactive oxygen species. Enhanced expression of these mediators causes RGCs loss by disruption of blood retinal barrier, excitotoxicity, and increased accumulation of intracellular Ca 2+ .…”

Section: Discussionmentioning

confidence: 99%

Peripapillary retina nerve fiber layer thickness and macular ganglion cell layer thickness in patients with obstructive sleep apnea syndrome

Kara

Sayın

Bayramoğlu

et al. 2017

Eye

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PurposeTo investigate the association of the severity of obstructive sleep apnea syndrome (OSAS) with peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL).Materials and methodsIn this cross-sectional study, 145 patients with OSAS and 40 healthy subjects were enrolled. OSAS patients were further divided into mild (n=50), moderate (n=36), and severe (n=59) OSAS groups according to their apnea-hypopnea index (AHI) values. Spectral-domain optical coherence tomography was used to measure the peripapillary RNFL and GC-IPL thicknesses.ResultsThere was no statistical difference between the RNFL thickness in OSAS and control groups (P>0.05). Both average GC-IPL and minimum GC-IPL thicknesses were significantly lower in severe OSAS group than in healthy controls (P<0.05 for both). There was a significant negative correlation between AHI and both average GC-IPL (r=-0.232, P=0.005) and minimum GC-IPL (r=-0.233, P=0.005) thicknesses.ConclusionsOur study results suggest that although RNFL thickness did not differ significantly between OSAS and control groups, ganglion cell layer thickness in OSAS patients is much lower than in healthy population. Ganglion cell thickness showed a significant correlation with the severity of OSAS.

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Section: Discussionmentioning

confidence: 99%

Peripapillary retina nerve fiber layer thickness and macular ganglion cell layer thickness in patients with obstructive sleep apnea syndrome

Kara

Sayın

Bayramoğlu

et al. 2017

Eye

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“…Finally, we used a simple utility in a website to combine sample size, mean, and standard deviation from multiple groups into 1 group instead of excluding the study. In the premier of this analysis, we included 2 studies[ 22 23 ] that the research objects were children with chronic upper airway obstructions (UAOs)/obstructive sleep apnea syndrome (OSAS) and children with sleep-disordered breathing. From the heterogeneity test results, P values of total, mild, and moderate OSAS were 0.024, 0.511, and 0.257, respectively.…”

Section: Discussionmentioning

confidence: 99%

Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome

et al. 2016

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Objective:To investigate the changes of retinal nerve fiber layer (RNFL) thickness in obstructive sleep apnea syndrome (OSAS) patients.Methods:Relevant studies were selected from 3 major literature databases (PubMed, Cochrane Library, and EMBASE) without language restriction. Main inclusion criteria is that a case-control study in which RNFL thickness was measured by a commercial available optical coherence tomography (OCT) in OSAS patients. Meta-analysis was performed using STATA 12.0 software. Efficacy estimates were evaluated by weighted mean difference with corresponding 95% confidence intervals (CIs). Primary outcome evaluations were: the average changes of RNFL thickness in total OSAS patients, subgroup analysis of RNFL thickness changes in patients of different OSAS stages, and subgroup analysis of 4-quadrant RNFL thickness changes in total OSAS patients.Results:Of the initial 327 literatures, 8 case-control studies with 763 eyes of OSA patients and 474 eyes of healthy controls were included (NOS scores ≥6). For the people of total OSAS, there had an average 2.92 μm decreased RNFL thickness compared with controls (95% CI: −4.61 to −1.24, P = 0.001). For subgroup analysis of OSAS in different stages, the average changes of RNFL thickness in mild, moderate, severe, and moderate to severe OSAS were 2.05 (95% CI: −4.40 to 0.30, P = 0.088), 2.32 (95% CI: −5.04 to 0.40, P = 0.094), 4.21 (95% CI: −8.36 to −0.06, P = 0.047), and 4.02 (95% CI: −7.65 to −0.40, P = 0.03), respectively. For subgroup analysis of 4-quadrant, the average changes of RNFL thickness in Superior, Nasal, Inferior, and Temporal quadrant were 2.43 (95% CI: −4.28 to −0.57, P = 0.01), 1.41 (95% CI: −3.33 to 0.51, P = 0.151), 3.75 (95% CI: −6.92 to −0.59, P = 0.02), and 0.98 (95% CI: −2.49 to 0.53, P = 0.203), respectively.Conclusion:Our study suggests that RNFL thickness in OSAS patients is much thinner than healthy population, especially in superior and inferior quadrant. The impact of OSAS disease on RNFL and visual function should be taken seriously in the further study.

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“…The fact that several studies found no differences in the ophthalmologic variables measured in OSA patients compared with controls, may be due to the possibility that OSA duration, rather than its severity, could be a more determining factor in the association with retinal diseases. 20,92,93 In this study, the onset of the disease remains uncertain because it was based on the patients' reports, which in most cases did not exceed 4 years. Therefore, OSA patients were evaluated in a baseline condition.…”

Section: Discussionmentioning

confidence: 98%

Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea

Duque-Chica

Gracitelli

Moura

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Citation: Duque-Chica GL, Gracitelli CPB, Moura ALA, et al. Contributions of the melanopsin-expressing ganglion cells, cones, and rods to the pupillary light response in obstructive sleep apnea. Invest Ophthalmol Vis Sci. 2019;60:3002-3012. https://doi.org/ 10.1167/iovs.19-26944 PURPOSE. To investigate the impact of obstructive sleep apnea (OSA) on the contribution of inner and outer retinal photoreceptors to the pupillary light response (PLR).METHODS. Ninety-three eyes from 27 patients with OSA and 25 healthy controls were tested. OSA severity was graded according to the apnea-hypopnea index. PLR was measured monocularly with an eye tracker in a Ganzfeld in response to 1-second blue (470 nm) and red (640 nm) flashes at À3, À2, À1, 0, 1, 2, and 2.4 log cd/m 2 . Peak pupil constriction amplitude, peak latency, and the postillumination pupil response were measured. The Cambridge Colour Test, standard automatic perimetry, spectral domain optical coherence tomography, polysomnography, and the Pittsburgh Sleep Quality Index were used.RESULTS. OSA patients have a significantly decreased peak pupil constriction amplitude for blue stimuli at À3, À2, À1, 1 log cd/m 2 and at all red flash luminances (P < 0.050), revealing reduction of outer retina contributions to PLR. OSA patients showed reduced peak latency for blue (À2, 0, 2, 2.4 log cd/m 2 ) and red stimuli (À2, 0 log cd/m 2 ; P < 0.040). No significant difference was found in the melanopsin-mediated PLR.CONCLUSIONS. This study is the first to evaluate the inner and outer retinal contributions to PLR in OSA patients. The results showed that the outer retinal photoreceptor contributions to PLR were affected in moderate and severe OSA patients. In contrast, the inner retina contributions to PLR are preserved.

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Thickness alterations of retinal nerve fiber layer in children with sleep-disordered breathing due to adenotonsillar hypertrophy

Cited by 13 publications

References 38 publications

Peripapillary retina nerve fiber layer thickness and macular ganglion cell layer thickness in patients with obstructive sleep apnea syndrome

Peripapillary retina nerve fiber layer thickness and macular ganglion cell layer thickness in patients with obstructive sleep apnea syndrome

Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome

Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea

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