Theta pulse stimulation: A natural stimulus pattern can trigger long-term depression but fails to reverse long-term potentiation in morphine withdrawn hippocampus area CA1

Hosseinmardi, Narges; Fathollahi, Yaghoub; Naghdi, Nasser; Javan, Mohammad

doi:10.1016/j.brainres.2009.08.020

Cited by 27 publications

(24 citation statements)

References 64 publications

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“…Although the FST provides information about mood (i.e., depression and anxiety) in rodents, it is important to use caution when extrapolating the data to humans. Our results are consistent with previous findings showing that withdrawal-related behavior from repeated morphine administration increased immobility during the FST [20]. Also, BER administration significantly decreased immobility and increased climbing behavior in the FST.…”

Section: Discussionsupporting

confidence: 93%

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee

Sur

Yeom

et al. 2012

Korean J Physiol Pharmacol

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The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression-and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic morphine withdrawal in rats. Male rats were exposed to chronic, intermittent, escalating morphine (10∼ 50 mg/kg) for 10 days. After the last morphine injection, depression-and anxiety-like beahvior associated with morphine discontinuation persisted for at least three days during withdrawal without any change in ambulatory activity. Daily BER administration significantly decreased immobility in the forced swimming test and increased open-arm exploration in the elevated plus maze test. BER administration also significantly blocked the increase in hypothalamic CRF expression and TH expression in the locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression. Taken together, these findings demonstrated that BER administration significantly reduced morphine withdrawal-associated behaviors following discontinuation of repeated morphine administration in rats, possibly through modulation of hypothalamic CRF and the central noradrenergic system. BER may be a useful agent for treating or alleviating complex withdrawal symptoms and preventing morphine use relapses.

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Section: Discussionsupporting

confidence: 93%

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee

Sur

Yeom

et al. 2012

Korean J Physiol Pharmacol

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show abstract

“…In inescapable situations, immobility reflects a passive coping strategy associated with resignation, which is a behavioral measure of emotional despair [41]. The current results are consistent with previous findings showing that behavior related to withdrawal from repeated morphine administration includes increased immobility during the FST [42]. Acupuncture stimulation of SP6 significantly decreased immobility and increased climbing behavior in the FST.…”

Section: Discussionsupporting

confidence: 91%

Acupuncture Stimulation Attenuates Impaired Emotional‐Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats

Lee

Sur

Shim

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The purpose of this study was to evaluate whether acupuncture stimulation attenuates withdrawal-induced behaviors in the rats during protracted abstinence following chronic morphine exposure. To do this, male rats were first exposed to morphine gradually from 20 to 100 mg/kg for 5 days, and subsequently naloxone was injected once to extend despair-related withdrawal behaviors for 4 weeks. Acupuncture stimulation was performed once at the SP6 (Sanyinjiao) acupoint on rat's; hind leg for 5 min during protracted abstinence from morphine. The acupuncture stimulation significantly decreased despair-like behavior deficits in the forced swimming test and low sociability in the open-field test as well as increased open-arm exploration in the elevated plus maze test in the last week of 4-week withdrawal period. Also the acupuncture stimulation significantly suppressed the increase in the hypothalamic corticotropin-releasing factor (CRF) expression, the decrease in the tyrosine hydroxylase expression in the locus coeruleus, and the decrease in the hippocampal brain-derived neurotrophic factor mRNA expression, induced by repeated injection of morphine. Taken together, these findings demonstrate that the acupuncture stimulation of SP6 significantly reduces withdrawal-induced behaviors, induced by repeated administration of morphine in rats, possibly through the modulation of hypothalamic CRF and the central noradrenergic system.

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“…Males were kept separated from females in cages until mating. In the morphine consumer groups (male and female groups), rats received morphine sulfate (TEMAD Co., Karaj, Alborz, IR) dissolved in drinking water (0.4 mg/ml) for 60 days (33,34). The control groups (male and female groups) received water.…”

Section: Experimental Groups and Morphine Consumptionmentioning

confidence: 99%

Transgenerational modification of hippocampus TNF-α and S100B levels in the offspring of rats chronically exposed to morphine during adolescence

Amri

Sadegh

Moulaei

et al. 2017

The American Journal of Drug and Alcohol Abuse

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Theta pulse stimulation: A natural stimulus pattern can trigger long-term depression but fails to reverse long-term potentiation in morphine withdrawn hippocampus area CA1

Cited by 27 publications

References 64 publications

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Acupuncture Stimulation Attenuates Impaired Emotional‐Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats

Transgenerational modification of hippocampus TNF-α and S100B levels in the offspring of rats chronically exposed to morphine during adolescence

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