Theta burst stimulation improves overt visual search in spatial neglect independently of attentional load

Cazzoli, Dario; Rosenthal, Clive R.; Kennard, Christopher; Zito, Giuseppe; Hopfner, Simone; Müri, René M.; Nyffeler, Thomas

doi:10.1016/j.cortex.2015.09.009

Cited by 23 publications

(24 citation statements)

References 54 publications

(3 reference statements)

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“…We excluded 15 studies for the following reasons: case report, case series, self-controlled study, review, and off-topic. The remaining 12 RCTs [ 14 , 50 – 60 ] with a total of 273 participants and four non-RCTs [ 61 – 64 ] with a total of 94 participants met the minimum requirements, and we included them in this review.…”

Section: Resultsmentioning

confidence: 99%

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Kashiwagi

Dib

Gomaa³

et al. 2018

Neural Plasticity

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Background Unilateral spatial neglect (USN) is the most frequent perceptual disorder after stroke. Noninvasive brain stimulation (NIBS) is a tool that has been used in the rehabilitation process to modify cortical excitability and improve perception and functional capacity. Objective To assess the impact of NIBS on USN after stroke. Methods An extensive search was conducted up to July 2016. Studies were selected if they were controlled and noncontrolled trials examining transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and theta burst stimulation (TBS) in USN after stroke, with outcomes measured by standardized USN and functional tests. Results Twelve RCTs (273 participants) and 4 non-RCTs (94 participants) proved eligible. We observed a benefit in overall USN measured by the line bisection test with NIBS in comparison to sham (SMD −2.35, 95% CI −3.72, −0.98; p = 0.0001); the rTMS yielded results that were consistent with the overall meta-analysis (SMD −2.82, 95% CI −3.66, −1.98; p = 0.09). The rTMS compared with sham also suggested a benefit in overall USN measured by Motor-Free Visual Perception Test at both 1 Hz (SMD 1.46, 95% CI 0.73, 2.20; p < 0.0001) and 10 Hz (SMD 1.19, 95% CI 0.48, 1.89; p = 0.54). There was also a benefit in overall USN measured by Albert's test and the line crossing test with 1 Hz rTMS compared to sham (SMD 2.04, 95% CI 1.14, 2.95; p < 0.0001). Conclusions The results suggest a benefit of NIBS on overall USN, and we conclude that rTMS is more efficacious compared to sham for USN after stroke.

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Section: Resultsmentioning

confidence: 99%

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Kashiwagi

Dib

Gomaa³

et al. 2018

Neural Plasticity

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“…Furthermore, two RCT-studies corroborated the above outcomes. 111,112 In recent years, researchers have also successfully applied inhibitory continuous Theta Burst Stimulation (cTBS) to the healthy hemisphere of individuals with USN in NRCT, 113,114 as well as in RCT-studies [115][116][117][118] observing long-lasting improved performance. Interestingly, Yang and colleagues 119 conducted a RCT study to compare behavioural and brain plasticity effects in USN individuals undergoing low-frequency rTMS, high-frequency rTMS, or cTBS.…”

Section: Transcranial Magnetic Stimulation (Tms)mentioning

confidence: 99%

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Gammeri¹,

Iacono²,

Ricci

et al. 2020

NDT

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Introduction: Unilateral spatial neglect (USN) is a disorder of contralesional space awareness which often follows unilateral brain lesion. Since USN impairs awareness of contralesional space/body and often of concomitant motor disorders, its presence represents a negative prognostic factor of functional recovery. Thus, the disorder needs to be carefully diagnosed and treated. Here, we attempted to present a clear and concise picture of current insights in the comprehension and rehabilitation of USN. Methods: We first provided an updated overview of USN clinical and neuroanatomical features and then highlighted recent progresses in the diagnosis and rehabilitation of the disease. In relation to USN rehabilitation, we conducted a MEDLINE literature research on three of the most promising interventions for USN rehabilitation: prismatic adaptation (PA), non-invasive brain stimulation (NIBS), and virtual reality (VR). The identified studies were classified according to the strength of their methods. Results: The last years have witnessed a relative decrement of interest in the study of neuropsychological disorders of spatial awareness in USN, but a relative increase in the study of potential interventions for its rehabilitation. Although optimal protocols still need to be defined, high-quality studies have demonstrated the efficacy of PA, TMS and tDCS interventions for the treatment of USN. In addition, preliminary investigations are suggesting the potentials of GVS and VR approaches for USN rehabilitation. Conclusion: Advancing neuropsychological and neuroscience tools to investigate USN pathophysiology is a necessary step to identify effective rehabilitation treatments and to foster our understanding of neurofunctional bases of spatial cognition in the healthy brain.

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“…Other studies have also demonstrated that the cortical neural correlates of saccadic eye movements and visual attention shifting overlap, and that these two aspects are functionally related ( Corbetta et al, 1998 ; Hoffman, 1998 ). Attention shifting and eye movements both rely upon a fronto-parietal network ( Bisley, 2011 ) and, due to neurodegenerative processes in this network, impairments in the control of visuo-spatial attention may result ( Cazzoli et al, 2015 ). In patients with AD, prominent deficits are present in the shifting of attention ( Parasuraman and Haxby, 1993 ), in the inhibition of shifting to irrelevant but salient spatial locations ( Danckert et al, 1998 ), in the shifting of the attentional focus between local and global features ( Filoteo et al, 1992 ), and in the ability to select the focus of attention ( Calderon et al, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Alzheimer’s Disease on Visual Target Detection: A “Peripheral Bias”

Vallejo

Cazzoli

Rampa

et al. 2016

Front. Aging Neurosci.

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Visual exploration is an omnipresent activity in everyday life, and might represent an important determinant of visual attention deficits in patients with Alzheimer’s Disease (AD). The present study aimed at investigating visual search performance in AD patients, in particular target detection in the far periphery, in daily living scenes. Eighteen AD patients and 20 healthy controls participated in the study. They were asked to freely explore a hemispherical screen, covering ±90°, and to respond to targets presented at 10°, 30°, and 50° eccentricity, while their eye movements were recorded. Compared to healthy controls, AD patients recognized less targets appearing in the center. No difference was found in target detection in the periphery. This pattern was confirmed by the fixation distribution analysis. These results show a neglect for the central part of the visual field for AD patients and provide new insights by mean of a search task involving a larger field of view.

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Theta burst stimulation improves overt visual search in spatial neglect independently of attentional load

Cited by 23 publications

References 54 publications

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review and Meta-Analysis of Randomized and Nonrandomized Controlled Trials

<p>Unilateral Spatial Neglect After Stroke: Current Insights</p>

Effects of Alzheimer’s Disease on Visual Target Detection: A “Peripheral Bias”

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