Thermosensitive self-assembled behavior of poly (acrylamide-co-acrylonitrile)/polystyrene triblock copolymer and application in drug loading

Li, Xian; Cai, Shuwei; Hu, Xiaolei; He, Xianru

doi:10.1080/00914037.2019.1706508

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Zhang et al [4] prepared a potential coating material based on CMC/PLA blend film. The biodegradable CMC/PVA blend film was successfully prepared by intra-and inter-molecular cross-linking reaction.…”

Section: Synthesis Of Pva/cmc Compositesmentioning

confidence: 99%

“…Blending of polymers can often produce materials with enhanced characteristics more rapidly compared to developing new polymer chemistry [1,2]. Extensive studies have been conducted on copolymers due to their high application potential [3][4][5][6][7][8] and their importance in basic science [9]. Developing new polymer blends with improved properties by mixing two or more polymers is usually a less time-consuming pro-cess than new polymer development with desired properties.…”

Section: Introductionmentioning

confidence: 99%

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A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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Section: Synthesis Of Pva/cmc Compositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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“…Polyacrylamide (PAAm) is a biocompatible polymer and has been widely used in bio-related areas, such as the control of cell functions, stem cell transplantation, cell culture, cell adhesion, and drug delivery systems. , PAAm has a H-acceptor (−CO) and H-donor (−N H 2 ). However, it cannot form interpolymer hydrogen bonds and show a UCST behavior in water due to the weak activity of its H-donor (−N H 2 ).…”

Section: Introductionmentioning

confidence: 99%

Design of a UCST Polymer with Strong Hydrogen Bonds and Reactive Moieties for Facile Polymer–Protein Hybridization

Sun

et al. 2022

Biomacromolecules

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Polymer–protein hybrids have been extensively used in biomedical fields. Polymers with upper critical solution temperature (UCST) behaviors can form a hydrated coacervate phase below the cloud point (T cp), providing themselves the opportunity to directly capture hydrophilic proteins and form hybrids in aqueous solutions. However, it is always a challenge to obtain a UCST polymer that could aggregate at a high temperature at a relatively low concentration and also efficiently bind with proteins. In this work, a UCST polymer reactive with proteins was designed, and its temperature responsiveness and protein-capture ability were investigated in detail. The polymer was synthesized by the reversible addition–fragmentation chain transfer (RAFT) polymerization of acrylamide (AAm) and N-acryloxysuccinimide (NAS). Interestingly, taking advantage of the partial hydrolysis of NAS into acrylic acid (AAc), the obtained P(AAm-co-NAS-co-AAc) polymer exhibited an excellent UCST behavior and possessed good protein-capture ability. It showed a relatively higher T cp (81 °C) at a lower concentration (0.1 wt %) and quickly formed polymer–protein hybrids with high protein loading and without losing protein bioactivity, and both the polymer and polymer–protein nanoparticles showed good cytocompatibility. All the findings are attributed to the unique structure of the polymer, which provided not only the strong and stable hydrogen bonds but also the quick and mild reactivity. The work offers an easy and mild strategy for polymer–protein hybridization directly in aqueous solutions, which may find applications in biomedical fields.

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“…Trithiocarbonates (TTCs) are widely used in medicine, biochemistry, organic synthesis, coordination chemistry, and polymer chemistry. , In this last domain, TTCs are well-known reversible addition–fragmentation chain transfer (RAFT) agents due to their high efficiency for the controlled polymerization of a large selection of monomers such as styrene and its derivatives, acrylamides, acrylates, and methacrylates . Many of them are commercially available in small quantities, and a few of them can be supplied at the industrial scale. , Unsymmetrical trithiocarbonates (e.g., R′ = n -alkyl, Scheme a) control the polymerization of the whole range of the aforementioned monomers, provided that the leaving group R is judiciously selected .…”

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confidence: 99%

Azo-Derived Symmetrical Trithiocarbonate for Unprecedented RAFT Control

et al. 2021

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Bis(2-cyanopropan-2-yl)trithiocarbonate (TTC-bCP) is a new symmetrical trithiocarbonate with the best leaving group ever reported for reversible addition–fragmentation chain transfer (RAFT) polymerization. We propose an elegant route to obtain TTC-bCP starting from 2,2′-azobis(2-methylpropionitrile) (AIBN) as a donor of the 2-cyanopropan-2-yl group. TTC-bCP allowed the preparation of a high-molar-mass (M n ≈ 135 kg mol–1) methyl methacrylate–n-butyl acrylate–methyl methacrylate triblock copolymer with unprecedented control (D̵ = 1.04) in reversible-deactivation radical polymerization. Rheology measurements of this triblock copolymer showed a typical thermoplastic elastomer behavior with a steady rubbery plateau up to 120 °C.

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Thermosensitive self-assembled behavior of poly (acrylamide-co-acrylonitrile)/polystyrene triblock copolymer and application in drug loading

Cited by 6 publications

References 29 publications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Design of a UCST Polymer with Strong Hydrogen Bonds and Reactive Moieties for Facile Polymer–Protein Hybridization

Azo-Derived Symmetrical Trithiocarbonate for Unprecedented RAFT Control

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