Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs

Bessa, Paulo C.; Machado, Raúl; Nürnberger, Sylvia; Dopler, Daniela; Banerjee, Asmita; Cunha, António M.; Rodríguez‐Cabello, José Carlos; Redl, Heinz; Griensven, Martijn van; Reis, Rui L.; Casal, Margarida

doi:10.1016/j.jconrel.2009.11.003

Cited by 161 publications

(117 citation statements)

References 33 publications

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“…Another interesting approach utilizing biological structures for drug delivery has been taken by several groups using amino acid based hydrogels [78,79]. Yoshida et al produced PNIPAAm hydrogels with polyamino acid crosslinked chains to produce thermoresponsive degradable hydrogels [78].…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

“…Rincon et al and Bessa et al synthesized elastin like polymers with polypeptide repeat units [79,80]. Elastin is a thermoresponsive polypeptide which has unique thermoresponsive ability.…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

“…Elastin is a thermoresponsive polypeptide which has unique thermoresponsive ability. Below its transition temperature it is solvated and extended in solution, however, above its LCST of 30 °C, the chains fold to form a nanoparticle, in particular it forms nanoparticles which entrap molecules inside their structure, allowing them to be used as a drug delivery vector [79,80]. Bessa showed that bone morphogenetic proteins could be encapsulated this way and delivered in a sustained way for 14 days to promote bone formation [79].…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

“…Below its transition temperature it is solvated and extended in solution, however, above its LCST of 30 °C, the chains fold to form a nanoparticle, in particular it forms nanoparticles which entrap molecules inside their structure, allowing them to be used as a drug delivery vector [79,80]. Bessa showed that bone morphogenetic proteins could be encapsulated this way and delivered in a sustained way for 14 days to promote bone formation [79]. Another interesting point is that these elastin particles are not recognized by the immune system giving a non toxic vector without further modification [79].…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

“…Bessa showed that bone morphogenetic proteins could be encapsulated this way and delivered in a sustained way for 14 days to promote bone formation [79]. Another interesting point is that these elastin particles are not recognized by the immune system giving a non toxic vector without further modification [79].…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

show abstract

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

“…Rincon et al and Bessa et al synthesized elastin like polymers with polypeptide repeat units [79,80]. Elastin is a thermoresponsive polypeptide which has unique thermoresponsive ability.…”

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

Section: Collapsed Network Swollen Networkmentioning

confidence: 99%

See 3 more Smart Citations

Thermoresponsive Polymers for Biomedical Applications

2011

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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Controlled‐Release Systems for Biologics

Oak¹,

Mandke²,

Layek³

et al. 2013

Pharmaceutical Sciences Encyclopedia

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It is evident by the progress in new drug delivery technologies that much attention has been devoted toward the way in which biologics are delivered. As shown in this chapter, present efforts in the field of delivery of biologics have accelerated and widened the possibility of their use with therapeutic agents for treatment of various chronic disorders. From the times when achieving a zero‐order release profile was just an imaginary concept and controlled release technology was known only to a few scientists, it has now been established widely and has gained significant applications in variety of fields ranging from gene therapy to tissue engineering.

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Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs

Cited by 161 publications

References 33 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Drug Delivery Systems

Controlled‐Release Systems for Biologics

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