Thermoresponsive polysaccharide-based composite hydrogel with antibacterial and healing-promoting activities for preventing recurrent adhesion after adhesiolysis

Zhang, Ershuai; Guo, Qi; Feng, Ji; Tian, Xinlu; Cui, Jing; Song, Yihang; Sun, Hong; Li, Junjie; Yao, Fanglian

doi:10.1016/j.actbio.2018.05.037

Cited by 91 publications

(51 citation statements)

References 45 publications

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“…It is necessary to note that an appropriate soaking time is very critical for the preparation of Janus adhesive hydrogel. Therefore, in the following experiment, the Janus hydrogels were prepared by fixing the ACG content at 20 wt% and the soaking time in COS solution was varied from 8 to 20 h (8,12,16, and 20 h). We note that the obtained Janus hydrogel soaked in COS solution for 8 h is not stable and the bottom face swells quickly in water ( Figure S7A, Supporting Information), since the side far away from the solution is less electrostatically crosslinked by COS within a shorter immersion time.…”

Section: Adhesion Properties Of the Janus Hydrogelsmentioning

confidence: 99%

“…[ 10,11 ] The formation of postoperative adhesions can cause severe consequences including chronic pelvic pain, ileus and infertility, which often require readmission and reoperation. [ 12,13 ] Currently, a variety of biomaterials have been reported to prevent postsurgical adhesion, [ 14–16 ] but they cannot replace surgical sutures for tissue repair due to lack of an adhesion ability to bond wet tissues. Therefore, it is of clinical significance to design and construct a bioadhesive that can robustly adhere to the wet tissues and prevent postsurgical tissue adhesion simultaneously.…”

Section: Introductionmentioning

confidence: 99%

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A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

Cui

Chen

et al. 2020

Adv Funct Materials

224

167

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Despite rapid development of adhesive hydrogels, the typical double-sided adhesives fail to adhere to wet tissues and concurrently prevent postoperative tissue adhesion, thus severely limiting their applications in repair of internal tissues. Herein, a negatively charged carboxyl-containing hydrogel is gradiently, electrostatically complexed with a cationic oligosaccharide by a one-sided dipping method to form a novel Janus hydrogel wet adhesive whose two-side faces demonstrate strikingly distinct adhesive and nonadhesive properties. The lightly complexed surface demonstrates instant robust adhesion to various wet biological tissues even under water since the phase separation induced by electrostatic complexation increases the hydrophobicity and water drainage capacity. Intriguingly, the highly complexed surface is non-adhesive due to complete neutralization of carboxyls in the hydrogels. The Janus hydrogel can be used to replace traditional sutures to treat gastric perforation of rabbits. Animal experiment outcomes reveal that one side of the Janus hydrogel is firmly glued to the stomach tissue, and other side facing outward can efficiently prevent the postoperative adhesion. Molecular simulation elucidates the importance for selecting cationic polymer species. It is believed that gradient polyelectrolyte complexation establish a new direction to create Janus adhesives for internal tissue/organ repair and simultaneous prevention of post-operative adhesion.

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Section: Adhesion Properties Of the Janus Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

Cui

Chen

et al. 2020

Adv Funct Materials

224

167

View full text Add to dashboard Cite

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“…The samples were tested under angular frequency sweep mode with a fixed shear strain of 1%. 16,26,27…”

Section: Gelation Properties Of Composite Solutionsmentioning

confidence: 99%

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

Dong¹,

Zhuang²,

Hao³

et al. 2020

IJN

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Introduction: Chronic trauma repair is an important issue affecting people's healthy lives. Thermo-sensitive hydrogel is injectable in situ and can be used to treat large-area wounds. In addition, antioxidants play important roles in promoting wound repair. Methods: The purpose of this research was to prepare a novel thermo-sensitive hydrogelpoly(N-isopropyl-acrylamide)/poly(γ-glutamic acid) (PP) loaded with superoxide dismutase (SOD) to improve the effect for trauma treatment. The micromorphology of the hydrogel was observed by scanning electron microscope and the physical properties were measured. The biocompatibility of hydrogel was evaluated by MTT experiment, and the effect of hydrogel on skin wound healing was evaluated by in vivo histological staining. Results: Gelling behavior and differential scanning calorimeter outcomes showed that the PP hydrogels possessed thermo-sensitivity at physiological temperature and the phase transformation temperature was 28.2°C. The high swelling rate and good water retention were conducive to wound healing. The activity of SOD in vitro was up to 85% at 10 h, which was advantageous to eliminate the superoxide anion. MTT assay revealed that this hydrogel possessed good biocompatibility. Dressings of PP loaded with SOD (SOD-PP) had a higher wound closure rate than other treatments in vivo in diabetic rat model. Discussion: The SOD-PP thermo-sensitive hydrogels can effectively promote wound healing and have good application prospects for wound repair.

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“…In situ‐forming thermoresponsive hydrogels have recently emerged as promising wound dressing materials (Chatterjee, Hui, & Kan, 2018; Galdoporpora et al, 2019; Yan et al, 2019). To be applied as efficient wound dressing materials, suitable in situ forming hydrogel candidates should possess several key features: fast in situ gelation with great stability; antibacterial properties, especially against drug‐resistant bacteria, such as MRSA; and clinically availability (Liu et al, 2019; Zhang et al, 2018). In this study, samples of PHN and PHN‐Cu were successively prepared to specifically investigate their ability to form hydrogels in situ and their wound healing capabilities.…”

Section: Discussionmentioning

confidence: 99%

A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu²⁺ solution sol–gel transition for wound protection and healing

et al. 2020

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Rapid and convenient wound healing is crucial for reducing potential post-traumatic wound complications. In this study, a temperature-sensitive polymer of poly-(HEMAco-NIPAM) (PHN) was synthesized by free-radical polymerization, in which the solution quickly underwent a sol-gel transition above 29 C, thus responding to a typical body temperature and facilitating wound sealing. PHN solution incorporated with copper ions (PHN-Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN-Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogenesis. Such a versatile, convenient aqueous solution could enable nonprofessionals to promptly treat wounds in a short time after injury, thus providing suitable conditions for later treatment, and can be used as a convenient method to clean wounds.

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Thermoresponsive polysaccharide-based composite hydrogel with antibacterial and healing-promoting activities for preventing recurrent adhesion after adhesiolysis

Cited by 91 publications

References 45 publications

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu²⁺ solution sol–gel transition for wound protection and healing

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Thermoresponsive polysaccharide-based composite hydrogel with antibacterial and healing-promoting activities for preventing recurrent adhesion after adhesiolysis

Cited by 91 publications

References 45 publications

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion

<p>Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application</p>

A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu2+ solution sol–gel transition for wound protection and healing

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A convenient approach by using poly‐(HEMA‐co‐NIPAM)/Cu²⁺ solution sol–gel transition for wound protection and healing