Thermomechanical Properties and Shape-Memory Capability of Drug Loaded Semi-Crystalline Polyestermethacrylate Networks

Neffe, Axel T.; Hanh, Bui Duc; Steuer, Susi; Wischke, Christian; Lendlein, Andreas

doi:10.1557/proc-1190-nn06-02

Cited by 7 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…N‐M‐C ) were selected as matrices, whereby three different SMP network architectures were realized based on i) oligo[( ϵ ‐caprolactone)‐ co ‐glycolide]dimethacrylate (CG‐DMA) telechelics, which were crosslinked by photopolymerization (Cat. N‐M‐C ),228, 229 ii) star‐shaped oligo[( ϵ ‐caprolactone)‐ co ‐glycolide]tetroles (oCG) (Cat. N‐M‐C ) or oligo[( rac ‐lactide)‐ co ‐glycolide]tetroles (oLG) (Cat.…”

Section: Multifunctionality Of Shape‐memory Polymersmentioning

confidence: 99%

Multifunctional Shape‐Memory Polymers

2010

Self Cite

View full text Add to dashboard Cite

The thermally‐induced shape‐memory effect (SME) is the capability of a material to change its shape in a predefined way in response to heat. In shape‐memory polymers (SMP) this shape change is the entropy‐driven recovery of a mechanical deformation, which was obtained before by application of external stress and was temporarily fixed by formation of physical crosslinks. The high technological significance of SMP becomes apparent in many established products (e.g., packaging materials, assembling devices, textiles, and membranes) and the broad SMP development activities in the field of biomedical as well as aerospace applications (e.g., medical devices or morphing structures for aerospace vehicles). Inspired by the complex and diverse requirements of these applications fundamental research is aiming at multifunctional SMP, in which SME is combined with additional functions and is proceeding rapidly. In this review different concepts for the creation of multifunctionality are derived from the various polymer network architectures of thermally‐induced SMP. Multimaterial systems, such as nanocomposites, are described as well as one‐component polymer systems, in which independent functions are integrated. Future challenges will be to transfer the concept of multifunctionality to other emerging shape‐memory technologies like light‐sensitive SMP, reversible shape changing effects or triple‐shape polymers.

show abstract

Section: Multifunctionality Of Shape‐memory Polymersmentioning

confidence: 99%

Multifunctional Shape‐Memory Polymers

2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the latter case, crosslinking via acrylates and urethanes have found wide application 25, 26. Chemically crosslinked polymer networks can be tailored to have a high elasticity, which is e.g., required for specific functionalities of the network such as the shape‐memory effect in general,2, 27–31 and furthermore for multifunctional materials such as the recently described networks combining controlled drug release, biodegradability, and shape‐memory 32–35…”

Section: Introductionmentioning

confidence: 99%

Controlled Change of Mechanical Properties during Hydrolytic Degradation of Polyester Urethane Networks

Neffe

Tronci

Alteheld

et al. 2010

Macro Chemistry & Physics

Self Cite

View full text Add to dashboard Cite

A. Alteheld Present Address: BASF Venture Capital GmbH, 4. Gartenweg -Z25, 67063 Ludwigshafen, Germany ---------Polyester urethane networks are versatile polymer systems as it is possible to tailor their mechanical properties and their hydrolytic degradation profile. For biomedical applications, the biodegradability as well as the thermomechanical properties of the polymer networks during the course of degradation is of importance. Therefore, we investigated the change of thermomechanical properties of networks based on star-shaped precursors of rac-dilactide and diglycolide, ε-caprolactone, or p-dioxanone, respectively, during hydrolytic degradation.Degradation rate and mechanical properties of the polymer networks were tailored by crosslink density, comonomers, and by changing the glass transition temperature. Most importantly, the degradation of the networks led to a controlled, step-by-step change of the mechanical properties of the networks. a Supporting information for this article is available at the bottom of the article's abstract page, which can be accessed from the journal's homepage at http://www.mrc-journal.de, or from the author. ((note: website is journal-specific)) b ATN and GT contributed equally to this work.-2 - IntroductionBiodegradable polymeric materials are the basis for implants needed for a certain time only and for which a second surgery for removal of the implant should be avoided, such as controlled drug release implants, [1] internal sutures, [2] and applications in tissue engineering and induced autoregeneration. [3,4] Principally, biodegradable materials are based on the cleavage of certain bonds under physiological conditions. The cleavage itself can happen through hydrolysis (e. g. of ester bonds), [5,6] by enzymatic cleavage, [7] or miscellaneous mechanisms such as reduction of disulfide bonds, [8] and can be in the main-or side chains, [9] depending on the monomers and architecture of the polymer. In biodegradable materials, cleavage of the bonds results in water soluble polymer fragments, which can be excreted from the body, e. g. through the kidney. [10] The degradation process of the polymer materials can be observed on different levels, including mass loss, change of molecular weight, change of thermomechanical properties, and the occurrence of degradation products. Additionally to degradation studies of bulk material, hydrolytic and enzymatic degradation can also be studied on polymer monolayers. [11] The degradation rate can generally be adjusted by the types of monomers, [12] the sequence structure and architecture of the polymer, [13][14][15][16] as well as by the morphology. One of the first and most-widely used classes of biodegradable polymers are the bulk degrading polyesters such as PLGA, however many other degradable materials are known such as poly(anhydrides), [17] poly(orthoesters), [18] poly(depsipeptides), [19] and poly(ether esters). [20] Semi-crystalline linear polyesters have been applied for sutures, for which mechanical stability is of high importance. O...

show abstract

“…The absence of any impact of drug incorporation on the thermal properties of the semicrystalline polymer network has clearly been shown for a library of PCGDMA-derived networks [137]. However, drug-loading levels of this network as obtained by the swelling technique remained low (<0.8 wt.%), at least for the studied model drugs [46].…”

Section: Smps Investigated As Drug-loaded Matrix Materialsmentioning

confidence: 87%

“…So far, controlled drug release has been established for covalent SMP networks that were based on different chemistries: PCGDMA as telechelics that were cross-linked by photo polymerization [46,137], oligo[(rac-lactide)-co-glycolide]tetroles (oLG) cross-linked by lowmolecular-weight aliphatic diisocyanates [131,138], and branched oligo(e-caprolactone)octols (oCl) cross-linked by low-molecularweight aliphatic diisocyanates [132]. These networks were of amorphous (oLG derived) and semi-crystalline (PCGDMA and oCl derived) morphology.…”

Section: Smps Investigated As Drug-loaded Matrix Materialsmentioning

confidence: 99%

Shape-memory polymers as a technology platform for biomedical applications

Lendlein

Behl

Hiebl

et al. 2010

Expert Review of Medical Devices

Self Cite

407

285

View full text Add to dashboard Cite

Polymeric materials are clinically required for medical devices, as well as controlled drug delivery systems. Depending on the application, the polymer has to provide suitable functionalities, for example, mechanical functions or the capability to actively move, so that an implant can be inserted in a compact shape through key-hole incisions and unfold to its functional shape in the body. Shape-memory polymers, as described herein regarding their general principle, compositions and architectures, have developed to a technology platform that allows the tailored design of such multifunctionality. In this way, defined movements of implants triggered either directly or indirectly, tailored mechanical properties, capability for sterilization, biodegradability, biocompatibility and controlled drug release can be realized. This comprehensive review of the scientific and patent literature illustrates that this technology enables the development of novel medical devices that will be clinically evaluated in the near future.

show abstract

Thermomechanical Properties and Shape-Memory Capability of Drug Loaded Semi-Crystalline Polyestermethacrylate Networks

Cited by 7 publications

References 6 publications

Multifunctional Shape‐Memory Polymers

Multifunctional Shape‐Memory Polymers

Controlled Change of Mechanical Properties during Hydrolytic Degradation of Polyester Urethane Networks

Shape-memory polymers as a technology platform for biomedical applications

Contact Info

Product

Resources

About