Abstract:Abbreviations:PSD95: postsynaptic density-95 protein; PDZ3: the third PDZ domain from PSD95;
Abstract (243 words)Differential scanning calorimetry (DSC) indicated that PDZ3 undergoes a peculiar thermal denaturation exhibiting two endothermic peaks due to the formation of reversible oligomers at high temperature (N↔I 6 ↔D). This contrasts sharply with the standard 2-state denaturation model observed for small, globular proteins. We performed an alanine scanning analysis by individually mutating three hydrophobi… Show more
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