Therapy of Spontaneous Ringworm in Cats with Orally Administered Griseofulvin

Efficacy of itraconazole oral solution using an alternating-week pulse therapy regimen for treatment of cats with experimental Microsporum canis infection

“…In addition, previously infected, but culturenegative, hairs often had residual fluorescence on the hair tips, as noted in other studies. 21,22 The high rate of negative Wood's lamp examinations at the base and mid-shaft of the hair and the rapid rate at which scores improved in the itraconazole-treated cats lends to the high level of effectiveness of itraconazole in the present study.…”

“…3,7,8,11,17,18 As the hair continues to grow after the organism has been killed, fluorescence will first disappear at the base of the hair, followed by the mid-shaft and eventually from the tip. 21,22 Thus, in the absence of fluorescence at the base of the hair, fluorescence mid-shaft or at the tip of the hair is not a sign of active infection. Wood's lamp examinations revealed rapid resolution of fluorescence at the base and mid-shaft of the hairs as early as week 1 of treatment.…”

Diagnosis and treatment of dermatophytosis in dogs and cats.

“…Adverse reactions were noted in four cats. Pruritus was the only adverse effect noted in one cat . In another study, three white cats developed clinical signs of malaise, with or without anorexia, pruritus, walking with a straddled gait, and a thick scruffy coat with brown scales and marked erythema .…”

“…Persian cats are commonly over‐represented in treatment studies, further supporting the observation that this breed is predisposed to dermatophytosis . For example, the first reports of the use of griseofulvin were in Persian cats; then in another example, Persian cats comprised a large part of each of the study groups reporting on the pharmacokinetic and pharmacodynamics of the dosing of itraconazole . Almost without exception, descriptions of subcutaneous dermatophytic infections are reported in long‐haired breeds, in particular, Persian cats …”

“…Data from that study showed that Persian cats were over‐represented; they accounted for 5% of all feline cases in the hospital but 24.6% of cats with dermatophytosis . Persian cats are commonly over‐represented in treatment studies, further supporting the observation that this breed is predisposed to dermatophytosis . For example, the first reports of the use of griseofulvin were in Persian cats; then in another example, Persian cats comprised a large part of each of the study groups reporting on the pharmacokinetic and pharmacodynamics of the dosing of itraconazole .…”