Therapy of Postsurgical Fungal Endophthalmitis

A rare case of endogenous Aspergillus conicus endophthalmitis in an immunocompromised patient

“…The species in our case, A . conicus , is rarely mentioned in the medical literature, and the only previous report of ophthalmic involvement was from a patient with postsurgical endophthalmitis [9]. A .…”

A rare case of endogenous Aspergillus conicus endophthalmitis in an immunocompromised patient

“…The species in our case, A . conicus , is rarely mentioned in the medical literature, and the only previous report of ophthalmic involvement was from a patient with postsurgical endophthalmitis [9]. A .…”

Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis

“…Foster and Stefanyszyn (15) reported that intravenous infusion of a 30-mg/kg dose of miconazole nitrate in rabbits produced peak aqueous humor levels of 7.9 jxg/ml at 1 h; no drug was detected in the vitreous body. Despite another initial report of good miconazole penetration into the eye (vitreous body concentration of 0.4 jig/ml 1 h after a 700-mg miconazole infusion and simultaneous serum concentration of 0.7 ,.g/ml [15,23]), parenteral miconazole was not effective in preventing the development of hematogenous Candida endophthalmitis in the rabbit model (24). Also, Blumenkranz and Stevens noted progression of ECE in a 19-year-old female heroin addict during intravenous miconazole therapy (5).…”

Candida endophthalmitis associated with intraocular lens implantation: efficacy of fluconazole therapy

“…Although a less common cause of fungaemia than C. albicans, C. parapsilosis is frequently implicated as a cause of infection in patients receiving total parenteral nutrition and in those with prosthetic devices, and is often a nosocomially acquired infection [ 13-161. C. parapsilosis appears to be less pathogenic than C. albicans or C. tropicalis on the basis of experimental animal studies [13], and patients with C. parapsilosis fungaemia appear to have a lower mortality than those with fungaemia due to C. albicans and C. tropicalis [ 13,14,161. Post-surgical exogenously acquired Candida endophthalmitis appears to be more difficult to treat than haematogenously acquired infection [21]. The infection is usually very low grade with minimal inflammation, thus leading to low concentrations of antifungal drugs in the tissues [7, 91.…”

A rare case of endogenous Aspergillus conicus endophthalmitis in an immunocompromised patient

“…The species in our case, A . conicus , is rarely mentioned in the medical literature, and the only previous report of ophthalmic involvement was from a patient with postsurgical endophthalmitis [9]. A .…”

Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis

“…Foster and Stefanyszyn (15) reported that intravenous infusion of a 30-mg/kg dose of miconazole nitrate in rabbits produced peak aqueous humor levels of 7.9 jxg/ml at 1 h; no drug was detected in the vitreous body. Despite another initial report of good miconazole penetration into the eye (vitreous body concentration of 0.4 jig/ml 1 h after a 700-mg miconazole infusion and simultaneous serum concentration of 0.7 ,.g/ml [15,23]), parenteral miconazole was not effective in preventing the development of hematogenous Candida endophthalmitis in the rabbit model (24). Also, Blumenkranz and Stevens noted progression of ECE in a 19-year-old female heroin addict during intravenous miconazole therapy (5).…”

Candida endophthalmitis associated with intraocular lens implantation: efficacy of fluconazole therapy

“…Although a less common cause of fungaemia than C. albicans, C. parapsilosis is frequently implicated as a cause of infection in patients receiving total parenteral nutrition and in those with prosthetic devices, and is often a nosocomially acquired infection [ 13-161. C. parapsilosis appears to be less pathogenic than C. albicans or C. tropicalis on the basis of experimental animal studies [13], and patients with C. parapsilosis fungaemia appear to have a lower mortality than those with fungaemia due to C. albicans and C. tropicalis [ 13,14,161. Post-surgical exogenously acquired Candida endophthalmitis appears to be more difficult to treat than haematogenously acquired infection [21]. The infection is usually very low grade with minimal inflammation, thus leading to low concentrations of antifungal drugs in the tissues [7, 91.…”

A rare case of endogenous Aspergillus conicus endophthalmitis in an immunocompromised patient

“…The species in our case, A . conicus , is rarely mentioned in the medical literature, and the only previous report of ophthalmic involvement was from a patient with postsurgical endophthalmitis [9]. A .…”

Penetration of new azole compounds into the eye and efficacy in experimental Candida endophthalmitis

“…Foster and Stefanyszyn (15) reported that intravenous infusion of a 30-mg/kg dose of miconazole nitrate in rabbits produced peak aqueous humor levels of 7.9 jxg/ml at 1 h; no drug was detected in the vitreous body. Despite another initial report of good miconazole penetration into the eye (vitreous body concentration of 0.4 jig/ml 1 h after a 700-mg miconazole infusion and simultaneous serum concentration of 0.7 ,.g/ml [15,23]), parenteral miconazole was not effective in preventing the development of hematogenous Candida endophthalmitis in the rabbit model (24). Also, Blumenkranz and Stevens noted progression of ECE in a 19-year-old female heroin addict during intravenous miconazole therapy (5).…”

Candida endophthalmitis associated with intraocular lens implantation: efficacy of fluconazole therapy

“…Although a less common cause of fungaemia than C. albicans, C. parapsilosis is frequently implicated as a cause of infection in patients receiving total parenteral nutrition and in those with prosthetic devices, and is often a nosocomially acquired infection [ 13-161. C. parapsilosis appears to be less pathogenic than C. albicans or C. tropicalis on the basis of experimental animal studies [13], and patients with C. parapsilosis fungaemia appear to have a lower mortality than those with fungaemia due to C. albicans and C. tropicalis [ 13,14,161. Post-surgical exogenously acquired Candida endophthalmitis appears to be more difficult to treat than haematogenously acquired infection [21]. The infection is usually very low grade with minimal inflammation, thus leading to low concentrations of antifungal drugs in the tissues [7, 91.…”