Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review

Arabzadeh, AmirAhmad; Mortezazadeh, Tohid; Aryafar, Tayebeh; Gharepapagh, Esmaeil; Majdaeen, Mehrsa; Farhood, Bagher

doi:10.1186/s12935-021-02099-0

Cited by 41 publications

(26 citation statements)

References 183 publications

(234 reference statements)

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“…21,[68][69][70][71] Oxidative stress is commonly recognized as one of the leading causes of chemotherapy-induced cardiotoxicity 20,82 ; as the amount of free radicals increases in this condition. [83][84][85][86] In this regard, doxorubicin can interact with oxygen molecules to form ROS in cardiac cells and subsequently cause elevated levels of oxidative stress. 87 The doxorubicin-generated ROS attack the cell macromolecules, leading to the malfunction of the heart tissue.…”

Section: Discussionmentioning

confidence: 99%

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

et al. 2022

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Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity. The use of curcumin may alleviate some of the doxorubicin‐induced cardiotoxic effects. Especially, using the nano‐formulation of curcumin can overcome the poor bioavailability of curcumin and enhance its physicochemical properties regarding its efficacy. In this study, we systematically reviewed the potential cardioprotective effects of nano‐curcumin against the doxorubicin‐induced cardiotoxicity. A systematic search was accomplished based on Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines for the identification of all relevant articles on “the role of nano‐curcumin on doxorubicin‐induced cardiotoxicity” in the electronic databases of Scopus, PubMed, and Web of Science up to July 2021. One hundred and sixty‐nine articles were screened following a predefined set of inclusion and exclusion criteria. Ten eligible scientific papers were finally included in the present systematic review. The administration of doxorubicin reduced the body and heart weights of mice/rats compared to the control groups. In contrast, the combined treatment of doxorubicin and nano‐curcumin increased the body and heart weights of animals compared with the doxorubicin‐treated groups alone. Furthermore, doxorubicin could significantly induce the biochemical and histological changes in the cardiac tissue; however, coadministration of nano‐curcumin formulation demonstrated a pattern opposite to the doxorubicin‐induced changes. The coadministration of nano‐curcumin alleviates the doxorubicin‐induced cardiotoxicity through various mechanisms including antioxidant, anti‐inflammatory, and antiapoptotic effects. Also, the cardioprotective effect of nano‐curcumin formulation against doxorubicin‐induced cardiotoxicity was higher than free curcumin.

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Section: Discussionmentioning

confidence: 99%

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

et al. 2022

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“…Among the important medicators involved in the apoptosis process are caspase enzymes, Bcl-2, p53, BAX, Bcl-XL, ceramide, PARP, nuclear factor of activated T cells 5 (NFAT5), and so on [ 76 – 87 ]. One of the characteristics of most cancerous cells is the evasion of apoptosis; as any reduction or irregularity of this pathway invariably accompanies tumorigenesis and maintains malignant progression [ 88 ]. Some chemotherapeutic agents are able to induce apoptosis in tumoral cells [ 89 , 90 ].…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities

et al. 2022

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Purpose 5-fluorouracil (5-FU), an effective chemotherapy drug, is commonly applied for colorectal cancer treatment. Nevertheless, its toxicity to normal tissues and the development of tumor resistance are the main obstacles to successful cancer chemotherapy and hence, its clinical application is limited. The use of resveratrol can increase 5-FU-induced cytotoxicity and mitigate the unwanted adverse effects. This study aimed to review the potential therapeutic effects of resveratrol in combination with 5-FU against colorectal cancer. Methods According to the PRISMA guideline, a comprehensive systematic search was carried out for the identification of relevant literature in four electronic databases of PubMed, Web of Science, Embase, and Scopus up to May 2021 using a pre-defined set of keywords in their titles and abstracts. We screened 282 studies in accordance with our inclusion and exclusion criteria. Thirteen articles were finally included in this systematic review. Results The in vitro findings showed that proliferation inhibition of colorectal cancer cells in the groups treated by 5-FU was remarkably higher than the untreated groups and the co-administration of resveratrol remarkably increased cytotoxicity induced by 5-FU. The in vivo results demonstrated a decrease in tumor growth of mice treated by 5-FU than the untreated group and a dramatic decrease was observed following combined treatment of resveratrol and 5-FU. It was also found that 5-FU alone and combined with resveratrol could regulate the cell cycle profile of colorectal cancer cells. Moreover, this chemotherapeutic agent induced the biochemical and histopathological changes in the cancerous cells/tissues and these alterations were synergized by resveratrol co-administration (for most of the cases), except for the inflammatory mediators. Conclusion The results obtained from this systematic review demonstrated that co-administration of resveratrol could sensitize the colorectal cancer cells to 5-FU treatment via various mechanisms, including regulation of cell cycle distribution, oxidant, apoptosis, anti-inflammatory effects.

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“…Furthermore, RES can successfully penetrate the BBB and, therefore, can be employed as an effective therapeutic or protective agent against CNS lesions/disorders and tumors, such as glioblastoma [ 131 ]. Some studies have also shown that RES, as a radio/chemo sensitizing agent, can improve the efficacy of radiotherapy/chemotherapy drugs against glioblastoma cells [ 132 ]. Below we examine in detail what is the chemopreventive and antitumor role of RES in glioblastoma.…”

Section: Natural Compounds In the Therapy Of Gliomamentioning

confidence: 99%

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

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Leporatti

2022

IJMS

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In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects.

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Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review

Cited by 41 publications

References 183 publications

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

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