Therapeutic Potential of Pentoxifylline in Paraquat-Induced Pulmonary
Toxicity: Role of the Phosphodiesterase Enzymes
Farshad Ghasemi,
Mobina Mohammadi,
Fatemeh Ghaffari
et al.
Abstract:Pentoxifylline (PTX), a non-selective phosphodiesterase inhibitor, has
demonstrated protective effects against lung injury in animal models. Given the
significance of pulmonary toxicity resulting from paraquat (PQ) exposure, the
present investigation was designed to explore the impact of PTX on PQ-induced
pulmonary oxidative impairment in male mice.Following preliminary studies, thirty-six mice were divided into six groups.
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