2011
DOI: 10.2337/db11-0807
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Abstract: OBJECTIVETo determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy.RESEARCH DESIGN AND METHODSDiabetes was induced in Nrf2+/+ and Nrf2−/− mice by STZ injection. Sulforaphane (SF) or cinnamic aldehyde (CA) was administered 2 weeks after STZ injection and metabolic indices and renal structure and function were assessed (18 weeks). Markers of diabe… Show more

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Cited by 446 publications
(352 citation statements)
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“…In contrast natural phytochemical Nrf2 activators such as sulforaphane, epigallocatechin-3-gallate, and curcumin, improve nephropathy in animal models of acute or chronic kidney diseases of diverse etiologies [19][20][21][22][23]. Together these observations support the role of Nrf2 deficiency in the pathogenesis of oxidative stress, inflammation, and progression of kidney disease.…”
Section: Introductionmentioning
confidence: 63%
See 1 more Smart Citation
“…In contrast natural phytochemical Nrf2 activators such as sulforaphane, epigallocatechin-3-gallate, and curcumin, improve nephropathy in animal models of acute or chronic kidney diseases of diverse etiologies [19][20][21][22][23]. Together these observations support the role of Nrf2 deficiency in the pathogenesis of oxidative stress, inflammation, and progression of kidney disease.…”
Section: Introductionmentioning
confidence: 63%
“…Activation of these pathways confers protection by up-regulating expression of antioxidant enzymes, detoxifying compounds, protein chaperones, and trophic factors. In fact these phytochemicals have been shown to prevent or ameliorate a variety of diseases including cardiovascular disease [42,43], neurodegenerative disorders [44][45][46][47][48][49], and acute and chronic kidney disease [19][20][21][22][23]. In contrast, excessive or unrestrained activity of Nrf2 system has been shown to have adverse consequences.…”
Section: Discussionmentioning
confidence: 99%
“…22 In streptozotocin-induced diabetes mellitus, Nrf2 activators reversed renal dysfunction and prevented kidney damage as evidenced by increase in urinary albumin excretion and urine albumin-to-creatinine ratio, as well as glomerular lesions, renal collagen, and ROS generation. 23 On the other hand, in Zucker diabetic fatty rats, a model of type 2 diabetes mellitus with progressive renal disease treatment with RTA 405, a bardoxolone analogue, caused worsening of proteinuria, glomerulosclerosis, and tubular damage. 24,25 Clinical studies have also shown discordant results.…”
Section: Discussionmentioning
confidence: 99%
“…Nrf2 activates the transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes, thereby eliciting protection against cellular threats such as oxidative stress and inflammation that are common in diabetic milieu [26]. Indeed, Nrf2-knockout mice were observed to suffer severe streptozotocin-induced diabetic kidney complications [27]. Moreover, pharmacological or dietary activation of Nrf2 resulted in the amelioration of kidney damage in a diabetic mouse model through the reduction of oxidative damage or ROS in those animals [28].…”
mentioning
confidence: 99%