Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota

Pan, Shijia; Yuan, Guo; Hong, Fan; Xu, Pengfei; Zhai, Yonggong

doi:10.1016/j.bbadis.2021.166281

Cited by 18 publications

(14 citation statements)

References 213 publications

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“…The pineal hormone induces endoplasmatic reticulum stress and increases gastric cancer cell apoptosis and autophagy [ 32 ]. In colorectal cancer, treatment induced apoptosis and inhibited cell proliferation, migration, and invasiveness [ 33 ], and increased cell death [ 34 ]. It also resulted in reduced cell viability and various cytotoxic effects in thyroid cancer cells [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts

Drobnik,

Tomaszewska,

Ryżko

et al. 2023

Pharmacol. Rep

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Background The extracellular matrix serves as a scaffold for cardiomyocytes, allowing them to work in accord. In rats, collagen metabolism within a myocardial infarction scar is regulated by melatonin. The present study determines whether melatonin influences matrix metabolism within human cardiac fibroblast cultures and examines the underlying mechanism. Methods The experiments were performed on cultures of cardiac fibroblasts. The Woessner method, 1,9-dimethylmethylene blue assay, enzyme-linked immunosorbent assay and quantitative PCR were used in the study. Results Melatonin treatment lowered the total cell count within the culture, elevated necrotic and apoptotic cell count as well as augmented cardiac fibroblast proliferation, and increased total, intracellular, and extracellular collagen within the fibroblast culture; it also elevated type III procollagen α1 chain expression, without increasing procollagen type I mRNA production. The pineal hormone did not influence matrix metalloproteinase-2 (MMP-2) release or glycosaminoglycan accumulation by cardiac fibroblasts. Melatonin increased the release of Fibroblast Growth Factor-2 (FGF-2) by human cardiac fibroblasts, but cardiotrophin release was not influenced. Conclusion Within human cardiac fibroblast culture, collagen metabolism is regulated by melatonin. The profibrotic effect of melatonin depends on the elevation of procollagen type III gene expression, and this could be modified by FGF-2. Two parallel processes, viz., cell elimination and proliferation, induced by melatonin, lead to excessive replacement of cardiac fibroblasts.

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Section: Discussionmentioning

confidence: 99%

Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts

Drobnik,

Tomaszewska,

Ryżko

et al. 2023

Pharmacol. Rep

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“…In addition to its role in sensitivity to chemotherapeutic agents, melatonin also sensitizes human CRC cells to γ-ray ionizing radiation both in vitro and in vivo ( 62 ). Interestingly, studies have pointed out that melatonin plays a preventive and therapeutic role in CRC by regulating lipid metabolism and gut microbiota ( 63 ). Menadione, a synthetic form of vitamin K, is known to stimulate an increase in intracellular ROS and alter the oxidative status of cancer cells ( 84 ).…”

Section: The Role Of Melatonin In Gi Cancermentioning

confidence: 99%

The mechanisms and roles of melatonin in gastrointestinal cancer

et al. 2022

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Gastrointestinal (GI) cancer is a global health problem with wide lesions and numerous cases. The increased morbidity and mortality of GI cancer is a socio-economic challenge for decades to come. Melatonin, a nature indolamine, exerts a crucial role in molecular interactions involved in multiple functional and physiological processes. Increasing evidence indicates that melatonin can modulate GI tract, decrease the occurrence of GI cancer, and enhance the sensitivity to chemoradiotherapy. However, little is known about the exact role of melatonin in anti-carcinogenesis. In this review, we discuss the action of the beneficial effects of melatonin in GI carcinogenesis. Furthermore, we compile the understanding of the role of melatonin in GI cancer, including esophageal cancer (EC), gastric cancer (GC), hepatocellular carcinoma (HCC), colorectal cancer (CRC), and pancreatic cancer (PC). In addition, the potential therapeutic application and clinical evaluation of melatonin in GI cancer are also discussed.

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“…Thus far, it has been reported that melatonin can regulate adipose tissue and adipokines, such as lipolysis of adipocyte, fat deposition, BAT growth, beige adipogenesis, and WAT browning, which in turn affects energy expenditure [ 74 ]. Especially, the possible mechanisms of melatonin-mediated signaling pathways in lipolysis and adipogenesis have been well summarized by Pan et al [ 75 ]. Melatonin could significantly induce lipolysis of adipocytes and up-regulate the expression of lipolytic genes and proteins via MT2, including hormone-sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL), and perilipin 1 (PLIN1) [ 76 ].…”

Section: Effect Of Melatonin On Obesitymentioning

confidence: 99%

Mechanisms of Melatonin in Obesity: A Review

Guan

Wang

Cao

et al. 2021

IJMS

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Obesity and its complications have become a prominent global public health problem that severely threatens human health. Melatonin, originally known as an effective antioxidant, is an endogenous hormone found throughout the body that serves various physiological functions. In recent decades, increasing attention has been paid to its unique function in regulating energy metabolism, especially in glucose and lipid metabolism. Accumulating evidence has established the relationship between melatonin and obesity; nevertheless, not all preclinical and clinical evidence indicates the anti-obesity effect of melatonin, which makes it remain to conclude the clinical effect of melatonin in the fight against obesity. In this review, we have summarized the current knowledge of melatonin in regulating obesity-related symptoms, with emphasis on its underlying mechanisms. The role of melatonin in regulating the lipid profile, adipose tissue, oxidative stress, and inflammation, as well as the interactions of melatonin with the circadian rhythm, gut microbiota, sleep disorder, as well as the α7nAChR, the opioidergic system, and exosomes, make melatonin a promising agent to open new avenues in the intervention of obesity.

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Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota

Cited by 18 publications

References 213 publications

Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts

Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts

The mechanisms and roles of melatonin in gastrointestinal cancer

Mechanisms of Melatonin in Obesity: A Review

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