Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats

Singhanat, Kodchanan; Apaijai, Nattayaporn; Sumneang, Natticha; Maneechote, Chayodom; Arunsak, Busarin; Chunchai, Titikorn; Chattipakorn, Nipon

doi:10.1007/s00018-022-04330-1

Cited by 9 publications

(3 citation statements)

References 63 publications

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“…The contribution of melatonin in maintaining mitochondrial redox homeostasis by influencing the tricarboxylic acid cycle, mitochondrial oxidative phosphorylation, SIRT3, and SOD2 has recently been revealed [32]. Consistent with our findings, a recent study has shown the therapeutic potential of single-dose melatonin in the attenuation of cardiac IR injury in prediabetic obese rats through its ability to improve mitochondrial function and rebalance the mitochondrial dynamics [20].…”

Section: Discussionsupporting

confidence: 90%

“…Melatonin increases the efficiency of mitochondrial oxidative phosphorylation and reduces electron leakage, thereby lowering free radical generation [15]. Interestingly, recent studies have shown that treatment with melatonin reduced mitochondrial dysfunction caused by cardiac ischemia-reperfusion injury in type 1 diabetic rats [19] as well as prediabetic obese rats [20].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin Reduces Aggravation of Renal Ischemia–Reperfusion Injury in Obese Rats by Maintaining Mitochondrial Homeostasis and Integrity through AMPK/PGC-1α/SIRT3/SOD2 Activation

Kobroob,

Kongkaew,

Wongmekiat

2023

CIMB

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This study examined the potential benefits of melatonin against renal ischemia and reperfusion (IR) injury in obesity and explored the underlying mechanisms. Obesity was induced in Wistar rats by feeding a high-fat diet for 16 weeks. Three obese groups that underwent renal IR induction (30-min renal ischemia followed by 24-h reperfusion) were randomly assigned to receive melatonin at ischemic onset, reperfusion onset, or pretreatment for 4 weeks before IR induction. Groups of vehicle-treated obese and normal-diet-fed rats that underwent sham or IR induction were also included in the study. The results showed that renal functional and structural impairments after IR incidence were aggravated in obese rats compared to normal-diet-fed rats. The obese-IR rats also exhibited oxidative stress, mitochondrial dysfunction, apoptosis, and mitochondrial dynamics and mitophagy imbalances, which were all considerably improved upon melatonin treatment, irrespective of the treatment time. This study suggests the prophylactic and therapeutic efficacy of melatonin in IR-induced acute kidney injury (AKI) in obese individuals, which may improve the prognosis of AKI in these populations. The benefits of melatonin are likely mediated by the modification of various signaling molecules within the mitochondria that maintain mitochondrial redox balance and lead to the protection of mitochondrial homeostasis and integrity.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Melatonin Reduces Aggravation of Renal Ischemia–Reperfusion Injury in Obese Rats by Maintaining Mitochondrial Homeostasis and Integrity through AMPK/PGC-1α/SIRT3/SOD2 Activation

Kobroob,

Kongkaew,

Wongmekiat

2023

CIMB

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“…Antioxidant effects were reported in Sprague–Dawley rats with myocardial ischemia/reperfusion injury, where MT decreased cardiac malondialdehyde while increasing cardiac SOD and GPx by activating the JAK2/STAT3 signaling pathway [ 134 ]. Similar results have been documented in other preclinical studies of cardiac ischemia/reperfusion injury [ 135 , 136 , 137 , 138 ]. Activation of cardiac MT2, but not MT1 receptors, may be responsible for this effect [ 139 ].…”

Section: Antioxidant Pharmacotherapies In Cardiorenal Diseasessupporting

confidence: 90%

Oxidative Stress Management in Cardiorenal Diseases: Focus on Novel Antidiabetic Agents, Finerenone, and Melatonin

Theofilis

Vordoni

Kalaitzidis

2022

Life

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Oxidative stress is characterized by excessive production of reactive oxygen species together with exhausted antioxidant defenses. This constitutes a main pathophysiologic process that is implicated in cardiovascular and renal diseases. In particular, enhanced oxidative stress may lead to low-density lipoprotein accumulation and oxidation, endothelial cell activation, adhesion molecule overexpression, macrophage activation, and foam cell formation, promoting the development and progression of atherosclerosis. The deleterious kidney effects of oxidative stress are numerous, including podocytopathy, mesangial enlargement, renal hypertrophy, tubulointerstitial fibrosis, and glomerulosclerosis. The prominent role of oxidative mechanisms in cardiorenal diseases may be counteracted by recently developed pharmacotherapies such as novel antidiabetic agents and finerenone. These agents have demonstrated significant antioxidant activity in preclinical and clinical studies. Moreover, the use of melatonin as a treatment in this field has been experimentally investigated, with large-scale clinical studies being awaited. Finally, clinical implications and future directions in this field are presented.

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New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases

Gu,

Wu,

2024

Am J Cardiovasc Drugs

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Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats

Cited by 9 publications

References 63 publications

Melatonin Reduces Aggravation of Renal Ischemia–Reperfusion Injury in Obese Rats by Maintaining Mitochondrial Homeostasis and Integrity through AMPK/PGC-1α/SIRT3/SOD2 Activation

Melatonin Reduces Aggravation of Renal Ischemia–Reperfusion Injury in Obese Rats by Maintaining Mitochondrial Homeostasis and Integrity through AMPK/PGC-1α/SIRT3/SOD2 Activation

Oxidative Stress Management in Cardiorenal Diseases: Focus on Novel Antidiabetic Agents, Finerenone, and Melatonin

New Perspectives on the Role and Therapeutic Potential of Melatonin in Cardiovascular Diseases

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