Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Abstract

ADHD-attention deficit hyperactivity disorder ASD-autism spectrum disorder CNS-central nervous system CRD-cysteine-rich domain CREB-cAMP response element binding protein CTD-C-terminal domain ELFN1/2-extracellular leucine-rich repeat and fibronectin type III domain-containing 1/2 GAD-glutamic acid decarboxylase GIRK-G protein-coupled inwardly rectifying potassium channel GPCR-G protein-coupled receptor GRK-G protein-coupled receptor kinase GWAS-genome-wide association study ICD-international classification of disease L-AP4-L-2-amino-4-phosphonobutyric acid LTP-long term potentiation MAPK-mitogen-activated protein kinase MECP2-methyl CpG-binding protein 2