volume 26, issue 4, P767-778 2011
DOI: 10.3233/jad-2011-110512
View full text
|
|
Share
Hasina Akhter, Ashwini Katre, Ling Li, Xuebo Liu, Rui-Ming Liu

Abstract: Alzheimer’s disease (AD) is a major cause of dementia in the elderly with no effective treatment. Accumulation of amyloid-β peptide (Aβ) in the brain, one of the pathological features of AD, is considered to be a central disease-causing and disease-promoting event in AD. In this study, we showed that feeding male AβPP/PS1 transgenic mice, a well established mouse model of AD, with a diet containing phenolic antioxidant tert-butylhydroquinone (TBHQ) dramatically reduced brain Aβ load with no significant effect…

expand abstract