Therapeutic lung lavage for meconium aspiration syndrome in newborn infants

Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate

“…69 Surfactant lavage for meconium aspiration was evaluated in a small, randomized trial; trends toward lower duration of ventilation and severity of illness were reported. 66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial.…”

“…66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial. 70 However, surfactant improved oxygenation and reduced the need for extracorporeal membrane oxygenation when parenchymal lung disease was present.…”

Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate

“…69 Surfactant lavage for meconium aspiration was evaluated in a small, randomized trial; trends toward lower duration of ventilation and severity of illness were reported. 66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial.…”

“…66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial. 70 However, surfactant improved oxygenation and reduced the need for extracorporeal membrane oxygenation when parenchymal lung disease was present.…”

Secondary surfactant administration in neonates with respiratory decompensation

“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17] This pilot study was designed to evaluate the magnitude of short-term effects of secondary surfactant administration in a population of premature infants with respiratory decompensation after recovery from RDS. We hypothesized that most of these acutely ill preterm infants would have derangement of surfactant production or activity and that administration of surfactant in these older infants would be well tolerated and result in improving blood gases and ventilator settings.…”

Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate

“…69 Surfactant lavage for meconium aspiration was evaluated in a small, randomized trial; trends toward lower duration of ventilation and severity of illness were reported. 66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial.…”

“…66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial. 70 However, surfactant improved oxygenation and reduced the need for extracorporeal membrane oxygenation when parenchymal lung disease was present.…”

Secondary surfactant administration in neonates with respiratory decompensation

“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17] This pilot study was designed to evaluate the magnitude of short-term effects of secondary surfactant administration in a population of premature infants with respiratory decompensation after recovery from RDS. We hypothesized that most of these acutely ill preterm infants would have derangement of surfactant production or activity and that administration of surfactant in these older infants would be well tolerated and result in improving blood gases and ventilator settings.…”

Surfactant-Replacement Therapy for Respiratory Distress in the Preterm and Term Neonate

“…69 Surfactant lavage for meconium aspiration was evaluated in a small, randomized trial; trends toward lower duration of ventilation and severity of illness were reported. 66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial.…”

“…66,72,78 However, the failure to complete the lavage procedure in 3 of 15 patients warrants additional safety studies. 72,78 Surfactant replacement for neonates with severe primary persistent pulmonary hypertension of the newborn did not significantly reduce the need for extracorporeal membrane oxygenation in a small clinical trial. 70 However, surfactant improved oxygenation and reduced the need for extracorporeal membrane oxygenation when parenchymal lung disease was present.…”

Secondary surfactant administration in neonates with respiratory decompensation

“…[4][5][6][7][8][9][10][11][12][13][14][15][16][17] This pilot study was designed to evaluate the magnitude of short-term effects of secondary surfactant administration in a population of premature infants with respiratory decompensation after recovery from RDS. We hypothesized that most of these acutely ill preterm infants would have derangement of surfactant production or activity and that administration of surfactant in these older infants would be well tolerated and result in improving blood gases and ventilator settings.…”