2006
DOI: 10.1152/ajplung.00480.2005
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: . Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol 291: L912-L922, 2006. First published July 7, 2006 doi:10.1152/ajplung.00480.2005.-Induction of hypercapnia by breathing high concentrations of carbon dioxide (CO2) may have beneficial effects on the pulmonary circulation. We tested the hypothesis that exposure to CO2 would protect against chronic pulmonary hypertension in newborn rats. Atmospheric CO2 was maintained at Ͻ0.5%… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

10
108
2

Year Published

2008
2008
2019
2019

Publication Types

Select...
6
1

Relationship

3
4

Authors

Journals

citations
Cited by 77 publications
(120 citation statements)
references
References 63 publications
10
108
2
Order By: Relevance
“…We have recently described a neonatal rat model of PHT secondary to chronic exposure to moderate hypoxia (13% O 2 ) from birth, which leads to increased oxidative stress in the lung (33). Herein, we confirmed in this model, using either of two structurally dissimilar ROS scavengers in vivo, a 21-aminosteroid, U74389G, or a piperidine nitroxide, Tempol, that ROS are critical to pulmonary vascular remodeling.…”
supporting
confidence: 52%
See 3 more Smart Citations
“…We have recently described a neonatal rat model of PHT secondary to chronic exposure to moderate hypoxia (13% O 2 ) from birth, which leads to increased oxidative stress in the lung (33). Herein, we confirmed in this model, using either of two structurally dissimilar ROS scavengers in vivo, a 21-aminosteroid, U74389G, or a piperidine nitroxide, Tempol, that ROS are critical to pulmonary vascular remodeling.…”
supporting
confidence: 52%
“…All procedures involving animals were performed in accordance with the standards of the Canadian Council on Animal Care and were approved by the Animal Care Committees of the Sunnybrook and Hospital for Sick Children Research Institutes. Each litter, maintained at n ϭ 10 -12 pups to control for nutritional effects, was nursed in either normoxia (21% O 2) or hypoxia (13% O2) from birth for up to 4, 7, or 14 days, as previously described in detail (33). This FIO 2 was chosen as the lowest that did not lead to excess mortality by 14 days (33).…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…All images were electronically stored using 3.5″ magneto optical disks and transferred to an electronic database for offline analysis using the EchoPac system. Specifically, measurements were taken to characterize LV performance, LVO, pulmonary hemodynamics, and LV afterload (see Supplementary Table S2 online) using previously published methods (38)(39)(40)(41). Lung wet:dry ratio.…”
Section: Vasopressin and Neonatal Resuscitationmentioning
confidence: 99%