Therapeutic Effects of Environmental Enrichment on Cognitive Function and Tissue Integrity Following Severe Traumatic Brain Injury in Rats

Passineau, Michael J.; Green, Edward J.; Dietrich, W. Dalton

doi:10.1006/exnr.2000.7623

Cited by 185 publications

(173 citation statements)

References 53 publications

Supporting

Mentioning

155

Contrasting

Unclassified

Order By: Relevance

“…There was also a significant main effect of group [F(2,27) = 18.93, p < 0.001), but not a group by trial interaction. Post hoc tests indicated that the FP+EE group and the sham group performed significantly better than the FP group (p < 0.001), which is in agreement with previous studies [28,35,59]. Swim speeds did not vary between groups.…”

Section: One-hour Of Daily Environmental Enrichment Attenuates Cognitsupporting

confidence: 90%

“…To determine if the experimental manipulations that we used in this study for the EE (1 h/d X 3 weeks) produced improvements in behavior following FP injury similar to those reported in previous studies (24 h/d X 2 weeks) [28,35,59], we added additional animals to the study and evaluated spatial learning and memory in a MWM across groups. In general, performance improved over trial blocks [F(3,36) = 32.75, p <0.001] for all groups (Fig.…”

Section: One-hour Of Daily Environmental Enrichment Attenuates Cognitmentioning

confidence: 99%

“…Environmental enrichment (EE) is a well established intervention for attenuating cognitive deficits associated with FP injury [4,28,35,59,76], as well as other experimental brain injury models [13,79]. Although our understanding of how EE mediates functional recovery after brain injury is incomplete, one explanation is that it promotes adaptations of surviving neural networks, enabling them to take over functions of damaged regions of the brain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Gaulke

Horner

Fink

et al. 2005

Molecular Brain Research

View full text Add to dashboard Cite

Neurons in the hilus of the dentate gyrus are lost following a lateral fluid percussion injury. Environmental enrichment is known to increase neurogenesis in the dentate in intact rats, suggesting that it might also do so following fluid percussion injury, and potentially provide replacements for lost neurons. We report that 1 hour of daily environmental enrichment for 3 weeks increased the number of progenitor cells in the dentate following fluid percussion injury, but only on the ipsilesional side. In the dentate granule cell layer, but not the hilus, most progenitors had a neuronal phenotype. The rate of on going cell proliferation was similar across groups. Collectively these results suggest that the beneficial effects of environmental enrichment on behavioral recovery following FP injury are not attributable to neuronal replacement in the hilus, but may be related to increased neurogenesis in the granule cell layer.

show abstract

Section: One-hour Of Daily Environmental Enrichment Attenuates Cognitsupporting

confidence: 90%

Section: One-hour Of Daily Environmental Enrichment Attenuates Cognitmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Gaulke

Horner

Fink

et al. 2005

Molecular Brain Research

View full text Add to dashboard Cite

show abstract

“…The workshop leaders focused exclusively on the potential for combinatorial pharmacological agents to promote recovery. While this is a commendable start, there is certainly real potential and value in including non-invasive therapies, such as environmental enrichment (EE) or exercise (Gomez-Pinilla et al, 2011;Griesbach et al, 2009;Hamm et al, 1996;Hicks et al, 2002;Hoffman et al, 2008;Kline et al, 2007Kline et al, ,2010Matter et al, 2011;Passineau et al, 2001;de Witt et al, 2011), in combinational therapy paradigms for promoting recovery and perhaps augmenting the pharmacological effects, particularly in rehabilitation settings.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Combined Treatment Paradigm Consisting of Environmental Enrichment and the 5-HT_1A Receptor Agonist Buspirone after Experimental Traumatic Brain Injury

Kline

Olsen

Sozda

et al. 2012

Journal of Neurotrauma

View full text Add to dashboard Cite

Environmental enrichment (EE) and serotonin 1A (5-HT 1A )-receptor agonists provide significant benefit after experimental traumatic brain injury (TBI). The aim of this study was to test the hypothesis that combining these therapies would produce an effect that is more robust than either therapy alone. Anesthetized adult male rats received a cortical impact or sham injury and then were randomly assigned to EE or standard (STD) housing where they received either buspirone (0.3 mg/kg) or vehicle (1.0 mL/kg) once daily for 3 weeks. Motor and cognitive assessments were conducted on post-injury days 1-5 and 14-19, respectively. CA1/3 neurons were quantified at 3 weeks. No differences were observed among buspirone and vehicle sham groups in any task regardless of housing condition and thus the data were pooled. CA3 cell loss was reduced in the TBI + EE + buspirone and TBI + EE + vehicle groups. Motor recovery, spatial learning, and memory retention were enhanced in the TBI + EE + buspirone, TBI + EE + vehicle, and TBI + STD + buspirone groups versus the TBI + STD + vehicle group ( p £ 0.005). Moreover, spatial learning was significantly better in the TBI + EE + buspirone group versus the TBI + STD + buspirone group ( p < 0.0001). No differences were revealed between the buspirone and vehicle EE groups. These data show that EE and buspirone benefit functional outcome after TBI, but their combination is not more robust than either alone, which does not support the hypothesis. The lack of an additive effect may be due to the early-and-continuous EE paradigm on its own producing marked benefits, resulting in a ceiling effect. The evaluation of buspirone in a delayed-and-abbreviated EE paradigm is ongoing in our laboratory.

show abstract

“…At the end of the 6 trials, the SHAM/VEH animals located the platform after an average of 8 ± 1 s compared to 36 ± 4 s for TBI/VEH (P<0.001 vs SHAM/VEH) and 33 ± 3 s for TBI/NT4 (P<0.001 vs SHAM/ VEH). It has been shown that LFP-injured and sham-injured rats do not differ in their swim speeds or paths in this model of TBI (Passineau et al, 2001, Lenzlinger et al, 2005.…”

Section: Nt-4/5 Treatment Does Not Improve Performance On Hippocampalmentioning

confidence: 79%

Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function

et al. 2007

View full text Add to dashboard Cite

Traumatic brain injury (TBI) causes selective hippocampal cell death which is believed to be associated with the cognitive impairment observed in both clinical and experimental settings. The endogenous neurotrophin NT-4/5, a TrkB ligand, has been shown to be neuroprotective for vulnerable CA3 pyramidal neurons after experimental brain injury. In this study, infusion of recombinant NT-4/5 increased survival of CA2/3 pyramidal neurons to 71% after lateral fluid percussion injury in rats, compared to 55% in vehicle-treated controls. The functional outcome of this NT-4/5-mediated neuroprotection was examined using three hippocampal-dependent behavioral tests. Injury-induced impairment was evident in all three tests, but interestingly, there was no treatment-related improvement in any of these measures. Similarly, injury-induced decreased excitability in the Schaffer collaterals was not affected by NT-4/5 treatment. We propose that a deeper understanding of the factors that link neuronal survival to recovery of function will be important for future studies of potentially therapeutic agents.

show abstract

Therapeutic Effects of Environmental Enrichment on Cognitive Function and Tissue Integrity Following Severe Traumatic Brain Injury in Rats

Cited by 185 publications

References 53 publications

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Evaluation of a Combined Treatment Paradigm Consisting of Environmental Enrichment and the 5-HT_1A Receptor Agonist Buspirone after Experimental Traumatic Brain Injury

Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function

Contact Info

Product

Resources

About

Therapeutic Effects of Environmental Enrichment on Cognitive Function and Tissue Integrity Following Severe Traumatic Brain Injury in Rats

Cited by 185 publications

References 53 publications

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Evaluation of a Combined Treatment Paradigm Consisting of Environmental Enrichment and the 5-HT1A Receptor Agonist Buspirone after Experimental Traumatic Brain Injury

Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function

Contact Info

Product

Resources

About

Evaluation of a Combined Treatment Paradigm Consisting of Environmental Enrichment and the 5-HT_1A Receptor Agonist Buspirone after Experimental Traumatic Brain Injury