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Cited by 23 publications
(32 citation statements)
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References 18 publications
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“…Gupta et al evidenced only a slightly quicker resolution of the severe respiratory distress (1 h) in the intervention group, which might not be clinically relevant. Similar results were reached in 2017 by Somnath and colleagues [ 166 ], who investigated the efficacy of a single high dose of vitamin D in the treatment of children hospitalized with ALRI, and found it did not influence the duration of hospital stay nor the secondary outcomes (mortality, PICU admissions, complications, etc.). A supplementation of 50,000 IU/day for 2 days was tried in Iran in children with pneumonia and it did not influence the severity of symptoms, however the study reported a lower duration of antibiotic use in the intervention group [ 166 ].…”
Section: Vitamin Dsupporting
confidence: 81%
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“…Gupta et al evidenced only a slightly quicker resolution of the severe respiratory distress (1 h) in the intervention group, which might not be clinically relevant. Similar results were reached in 2017 by Somnath and colleagues [ 166 ], who investigated the efficacy of a single high dose of vitamin D in the treatment of children hospitalized with ALRI, and found it did not influence the duration of hospital stay nor the secondary outcomes (mortality, PICU admissions, complications, etc.). A supplementation of 50,000 IU/day for 2 days was tried in Iran in children with pneumonia and it did not influence the severity of symptoms, however the study reported a lower duration of antibiotic use in the intervention group [ 166 ].…”
Section: Vitamin Dsupporting
confidence: 81%
“…Similar results were reached in 2017 by Somnath and colleagues [ 166 ], who investigated the efficacy of a single high dose of vitamin D in the treatment of children hospitalized with ALRI, and found it did not influence the duration of hospital stay nor the secondary outcomes (mortality, PICU admissions, complications, etc.). A supplementation of 50,000 IU/day for 2 days was tried in Iran in children with pneumonia and it did not influence the severity of symptoms, however the study reported a lower duration of antibiotic use in the intervention group [ 166 ]. Contrasting evidence was found in a 2015 Egyptian trial on children hospitalized for bronchiolitis [ 161 ], where the administration of vitamin D 100 IU/kg/day for 5 days was associated with a significant improvement in the duration of hospitalization and time taken to improve oral feeding.…”
Section: Vitamin Dsupporting
confidence: 81%
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“…Vitamin D deficiency increases the risk of upper and lower airway infections [ 49 , 50 ]. Many studies have shown that low vitamin D levels are associated with respiratory tract infections and that vitamin D supplements exert beneficial effects during the treatment of infectious diseases [ 51 , 52 ], although some randomized controlled trials found that vitamin D afforded no benefit in those treated for infectious diseases [ 53 55 ]. A recent systematic review and meta-analysis reported that vitamin D supplements had a protective effect against acute respiratory infection, particularly in patients with profound vitamin D deficiency [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, the potential role of vitamin D as an adjunctive treatment for acute respiratory infections is still unclear. Randomised controlled trials in children using either a single large dose 7 9 or smaller daily doses 10 showed no change in the resolution of acute clinical features and inconsistent results in preventing recurrence of pneumonia despite a high prevalence of vitamin D deficiency 7 10 . There are no studies reported for lower respiratory tract infections in adults except in tuberculosis where adjunctive vitamin D has been shown to hasten sputum culture conversion but only in those patients who have the vitamin D receptor T aqI tt genotype 11 .…”
Section: Introductionmentioning
confidence: 99%