Therapeutic effect of adipose-derived mesenchymal stem cell injection in horses suffering from bone spavin

Abstract

In this article we demonstrate the efficiency of autologous transplantations of adipose-derived mesenchymal stem cells for equine bone spavin treatment. Horses qualified to the study were divided into three groups: (i) research -treated with intra-articular injections of autologous stem cells, (ii) comparison treated with steroid drugs and (iii) control -untreated. All animals underwent comprehensive clinical examination before and after treatment. Our research confirms the long-term beneficial influence resulting from stem cell therapy in horse bone spavin treatment, in contrast to routine steroid usage.

The effect of low static magnetic field on osteogenic and adipogenic differentiation potential of human adipose stromal/stem cells

“…This is because of their high viability and ease of obtaining in large quantities with little donor site related complications or patient discomfort. Cellular therapies based on ASCs have been shown to be both safe and effective in pre-and clinical studies -both in veterinary, as well as human medicine [7][8][9] These stem cells posses the unique ability to differentiate into chondrocytes, osteoblasts and adipocytes, and recently also their differentiation potential into neuronal precursor cells has been demonstrated [10,11]. Beside self-renewal and multipotency ASCs have been demonstrated to display immunomodulatory effects by Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/jmmm interacting both with natural, as well as adoptive immune responses [12,13].…”

Adipose-derived mesenchymal stem cells from the elderly exhibit decreased migration and differentiation abilities with senescent properties

“…Nicpon et al confirms the long-term beneficial influence resulting from ASC therapy in horse bone spavin treatment, in contrast to routine steroid usage. 2 ASCs also have been used as a cell therapy in several human clinical trials, including those on soft tissue augmentation, idiopathic pulmonary fibrosis, 3 and myocardial ischemia.…”

The Advantages of Autologus Adipose Derived Mesenchymal Stem Cells (AdMSCs) over the NSAIDs Application for Degenerative Elbow Joint Disease Treatment in Dogs - Twelve Cases

“…Most likely it may be caused by the paracrine effect of stem cells, which when introduced into an inflammatory environment, respond by shedding mesenchymal microvesicles (mMVs), as was reported by other groups [22] . An additional advantage of stem cell therapy is the immunomodulatory action of MSC [23] , which leads to a decrease in local joint inflammation. Therefore, we can conclude that auto-transplantations of adipose-derived mesenchymal stem cells may also be utilized as anti-inflammatory agent, without causing adverse reactions seen after prolonged NSAIDS application.…”