Therapeutic effect and toxicity of adriamycin in patients with neoplastic disease

Effect of Adriamycin Entrapped in Sulfatide-Containing Liposomes on Colon Tumor Cells Metastasized.

“…Adriamycin, an anthracyclin antibiotic with a remarkable antineoplastic effect, is known to induce an irreversible cardiotoxicity, and so cannot be given as a cumulative dosage [2][3][4][5] . Accordingly the entrapment of this drug in various types of liposomes to decrease its uptake by the heart without a reduction in its antineoplastic activity has been extensively attempted.…”

“…Adriamycin (ADM), an anthracycline antibiotic, is one of the most effective drugs against various types of neoplasms such as solid tumors and leukemia [1] . However, its clinical application is limited by its cardiotoxicity that arises from cumulative treatment [2][3][4][5]. For reduction of such toxicity, entrapment of ADM into negatively charged liposomes has been successfully done without a decrease in its antineoplastic activity [6][7][8][9][10][11][12][13][14][15].…”

Experimental chemotherapy-induced skin necrosis in swine. Mechanistic studies of anthracycline antibiotic toxicity and protection with a radical dimer compound.

“…Skin injury resulting from extravasation of necrotizing chemotherapeutic agents accounts for 1-5% of all chemotherapy-related toxicities (1). Extravasation ofdoxorubicin, a widely used anthracycline antibiotic, is a well-recognized complication of its use with an estimated incidence of 0.5 to 6% (2)(3)(4). Mitomycin C and the vinca alkaloids are also necrotizing antitumor drugs that cause tissue injury after extravasation (5,6).…”

Preparation and Some Properties of Cholesterol Sulfate-Containing Liposomes Entrapping Adriamycin.

“…ADM is a glycosidic anthracycline antibiotic that is a fermentation product of the fungus, Streptomyces peucetus caesius [2], and possesses a tetracycline ring structure with positively charged daunosamine attached to it through a glycosidic linkage [3]. This drug is known to be useful for the treatment of leukemias and solid tumors [2,4]. However, it attacks heart muscle to cause irreversible injury [4][5][6].…”

“…This drug is known to be useful for the treatment of leukemias and solid tumors [2,4]. However, it attacks heart muscle to cause irreversible injury [4][5][6]. As a result, serious cardiotoxicity has limited the clinical use of this drug for the treatment of neoplasms.…”