Therapeutic Angiogenesis by Transplantation of Human Embryonic Stem Cell-Derived CD133
            <sup>+</sup>
            Endothelial Progenitor Cells for Cardiac Repair

Rufaihah, Abdul Jalil; Haider, Husnain Kh; Heng, Boon Chin; Ye, Lei; Tan, Ru San; Toh, Wei Seong; Tian, Xian Feng; Sim, Eugene K.W.; Cao, Tong

doi:10.2217/rme.09.83

Cited by 58 publications

(16 citation statements)

References 54 publications

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“…EPCs or CD34 positive/CD133 positive cells have been demonstrated to repair the denuded vessel walls and to promote renewal of endothelium (Rufaihah et al, 2010;Senegaglia et al, 2010;Walter et al, 2002). CD34 positive cells play an indispensable role in angiogenesis (Al-Jarrah et al, 2010;Stellos et al, 2010;Wang et al, 2010).…”

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confidence: 99%

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Wang

Kan

et al. 2012

Journal of Neurotrauma

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Vascular remodeling plays a key role in neural regeneration in the injured brain. Circulating endothelial progenitor cells (EPCs) are a mediator of the vascular remodeling process. Previous studies have found that progesterone treatment of traumatic brain injury (TBI) decreases cerebral edema and cellular apoptosis and inhibits inflammation, which in concert promote neuroprotective effects in young adult rats. However, whether progesterone treatment regulates circulating EPC level and fosters vascular remodeling after TBI have not been investigated. In this study, we hypothesize that progesterone treatment following TBI increases circulating EPC levels and promotes vascular remodeling in the injured brain in aged rats. Male Wistar 20-month-old rats were subjected to a moderate unilateral parietal cortical contusion injury and were treated with or without progesterone (n = 54/group). Progesterone was administered intraperitoneally at a dose of 16mg/kg at 1 h post-TBI and was subsequently injected subcutaneously daily for 14 days. Neurological functional tests and immnunostaining were performed. Circulating EPCs were measured by flow cytometry. Progesterone treatment significantly improved neurological outcome after TBI measured by the modified neurological severity score, Morris Water Maze and the long term potentiation in the hippocampus as well as increased the circulating EPC levels compared to TBI controls ( p < 0.05). Progesterone treatment also significantly increased CD34 and CD31 positive cell number and vessel density in the injured brain compared to TBI controls ( p < 0.05). These data indicate that progesterone treatment of TBI improves multiple neurological functional outcomes, increases the circulating EPC level, and facilitates vascular remodeling in the injured brain after TBI in aged rats.

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confidence: 99%

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Wang

Kan

et al. 2012

Journal of Neurotrauma

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“…Additionally, replenishing the lack of EPCs in TAO patients has a more direct mode of action and can be used for the prevention as well as the treatment of TAO. Several studies have suggested the use of EPCs for therapeutic purposes in other diseases, [36][37][38] and the results were promising. Since studies of EPC injection in TAO have not been performed yet, this could be another possible target for further studies.…”

Section: Discussionmentioning

confidence: 99%

Reduced circulating endothelial progenitor cells in thromboangiitis obliterans (Buerger’s disease)

et al. 2013

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To determine the role of endothelial progenitor cells (EPCs) in the pathogenesis of thromboangiitis obliterans (TAO), EPC numbers and colony-forming units, migratory function and tubular structure formation in vitro were compared between 13 young male TAO patients and two age-matched healthy control groups: 11 smokers and 12 non-smokers. TAO patients had significantly lower numbers of EPCs and EPC colonies compared to both non-smokers [190 (97.0-229) . However, there were no significant differences in migratory function or tube formation between the three groups. These results suggest that TAO patients have an intrinsic decrease in EPCs not entirely associated with smoking, which may be the cause of endothelial dysfunction seen in TAO patients leading to the development of this disease at early ages.

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“…To date, several diverse cell types have been derived from hESCs, including cardiomyocytes [66,67], endothelial cells [68][69][70], chondrocytes [71][72][73][74][75], osteoblasts [76][77][78], neurons [79][80][81], keratinocytes [82,83], and hepatocytes [84].…”

Section: Embryonic Stem Cellsmentioning

confidence: 99%

Stem Cells for Temporomandibular Joint Repair and Regeneration

Zhang

Yap

Toh

2015

Stem Cell Rev and Rep

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Temporomandibular Disorders (TMD) represent a heterogeneous group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint (TMJ), masticatory muscles and/or associated structures. They are a major cause of non-dental orofacial pain. As a group, they are often multi-factorial in nature and have no common etiology or biological explanations. TMD can be broadly divided into masticatory muscle and TMJ disorders. TMJ disorders are characterized by intra-articular positional and/or structural abnormalities. The most common type of TMJ disorders involves displacement of the TMJ articular disc that precedes progressive degenerative changes of the joint leading to osteoarthritis (OA). In the past decade, progress made in the development of stem cell-based therapies and tissue engineering have provided alternative methods to attenuate the disease symptoms and even replace the diseased tissue in the treatment of TMJ disorders. Resident mesenchymal stem cells (MSCs) have been isolated from the synovia of TMJ, suggesting an important role in the repair and regeneration of TMJ. The seminal discovery of pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have provided promising cell sources for drug discovery, transplantation as well as for tissue engineering of TMJ condylar cartilage and disc. This review discusses the most recent advances in development of stem cell-based treatments for TMJ disorders through innovative approaches of cell-based therapeutics, tissue engineering and drug discovery.

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Therapeutic Angiogenesis by Transplantation of Human Embryonic Stem Cell-Derived CD133 ⁺ Endothelial Progenitor Cells for Cardiac Repair

Abstract: hESC-derived CD133(+) endothelial progenitor cells can be utilized to regenerate the infarcted heart.

Cited by 58 publications

References 54 publications

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Reduced circulating endothelial progenitor cells in thromboangiitis obliterans (Buerger’s disease)

Stem Cells for Temporomandibular Joint Repair and Regeneration

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Therapeutic Angiogenesis by Transplantation of Human Embryonic Stem Cell-Derived CD133 + Endothelial Progenitor Cells for Cardiac Repair

Abstract: hESC-derived CD133(+) endothelial progenitor cells can be utilized to regenerate the infarcted heart.

Cited by 58 publications

References 54 publications

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Progesterone Increases Circulating Endothelial Progenitor Cells and Induces Neural Regeneration after Traumatic Brain Injury in Aged Rats

Reduced circulating endothelial progenitor cells in thromboangiitis obliterans (Buerger’s disease)

Stem Cells for Temporomandibular Joint Repair and Regeneration

Contact Info

Product

Resources

About

Therapeutic Angiogenesis by Transplantation of Human Embryonic Stem Cell-Derived CD133 ⁺ Endothelial Progenitor Cells for Cardiac Repair