Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats

Coqueiro, Raildo da Silva; Soares, Telma de Jesus; Pereira, Rafael; Correia, Thiago Macêdo Lopes; Coqueiro, Danila Souza Oliveira; Oliveira, Márcio Vasconcelos; Marques, Lucas Miranda; Sá, Cloud Kennedy Couto de; Magalhães, Amélia Cristina Mendes de

doi:10.1016/j.clnesp.2018.10.003

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…Nevertheless, the physical training resulted in BW control in the SHR-Dexa-TR and SHR-Dexa-OL-TR groups. There is evidence that physical exercise promotes not only the maintenance but also BW loss in obese rodent models (COQUEIRO et al, 2019). The maintenance of BW in adult SHR-Dexa animals verified in the present study can be explained by an imbalance between lipolysis and lipogenesis (YOSHIMU-RA et al, 2018), with consequent increase in energy expenditure because of exercise performed.…”

Section: Discussionsupporting

confidence: 63%

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Fernandes¹,

Oltramari²,

Nardo³

et al. 2021

Rev. Cont. Saúde

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Metabolic syndrome (MetSyn) is a disorder that involves a series of symptoms that are associated to obesity and metabolic modifications, and increases the risk of developing cardiovascular disease and type 2 diabetes Mellitus. The study of new possibilities of non-drug therapies is fundamental for the primary prevention of MetSyn. The aim of this work was to evaluate the responses of spontaneously hypertensive rats (SHR) with lipid changes induced by the administration of dexamethasone (DEXA) to the ingestion of flaxseed oil associated or not associated with physical exercise regarding the body weight, and glycemic and lipid profiles, in comparison with the drug treatment with metformin. After 24 days of experiment, the 20-week-old animals were submitted to the glucose tolerance test (GTT) and lipid profile evaluation. The results showed that the administration of DEXA in SHR animals promoted a framework of hyperglycemia, dyslipidemia and attenuated the insulin resistance common in the SHR, thus producing an experimental model with several components of the human MetSyn. The effects on weight gain indicated an important preventive action of flaxseed oil and exercise on the weight evolution of SHR-DEXA animals. Furthermore, the ingestion of flaxseed oil associated or not with exercise promoted significant improvements on hyperglycemia and glucose intolerance in these animals. Regarding the lipid profile, the treatments with flaxseed oil and exercise promoted reductions in triglyceride levels and HDL-c increase; however, the combination of these two non-drug interventions was more effective than the isolated treatments.

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Section: Discussionsupporting

confidence: 63%

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Fernandes¹,

Oltramari²,

Nardo³

et al. 2021

Rev. Cont. Saúde

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“…Tbc1d1 expression was significantly increased in diabetic Goto-Kakizaki rats muscle [15]. Preventive and therapeutic exercise group of rats (in comparison to sedentary group) exhibited increased Tbc1d1 expression in soleus and gastrocnemius muscles [32]. Myocardial infarct induces the expression of Tbc1d1 in murine heart muscle both in infarct zone and border zone [25].…”

Section: Discussionmentioning

confidence: 97%

“…We have observed no significant effect of adipokines and myokines on both genes expression in cultured human subcutaneous adipocytes. Plethora of methods was used to determine the abundance of TBC1D1 and TBC1D4 on protein and mRNA level, including Western blotting [16,19,20,21,22,23,24,25,12,26,27,28,11,29,14], Reverse Transcription PCR (RT-PCR) [22], quantitative PCR (qPCR) [23,20,30,31,12,26,27,32,28,33,14], microarray [20] and RNA sequencing (RNA-seq) with qPCR validation [34,13,15].…”

Section: Discussionmentioning

confidence: 99%

No evidence for change in expression of TBC1D1 and TBC1D4 genes in cultured human adipocytes stimulated by myokines and adipokines

et al. 2021

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TBC1D1 and TBC1D4 proteins play analogous, but not identical role in governing insulin-signalling pathway. Little is known about changes in expression levels of TBC1D1 and TBC1D4 genes in mammals, including humans. Number of factors were studied, but data remain controversial. The aim of this study was to evaluate the effect of selected cytokines, adipokines and myokines with known or putative insulin sensitivity regulation activity (adiponectin, irisin, omentin, interleukin 6, leptin, resistin, and tumour necrosis factor) on TBC1D1 and TBC1D4 expression levels in cultured differentiated human adipocytes. No significant differences were found between the adipocytes treated with different stimuli and this effect was determined not dose dependent. It is reasonable to conclude that relative shortage of data showing no change in TBC1D1 and TBC1D4 from literature results from publication bias; therefore, our finding provides additional insight into the role of both genes.

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“…To calculate the sample size, we used the mean difference formula between the two groups with 95% confidence and 90% power and using the results of da Silva et al 15 The sample size by using the formula below equals six (n = 6) and with a 20% probability of loss, the sample size was assumed 7 rats for each group (n = 7).…”

Section: Animals and Study Designmentioning

confidence: 99%

Exercise improves aging-related decreased angiogenesis through modulating VEGF-A, TSP-1 and p-NF-Ƙb protein levels in myocardiocytes

Pourheydar

Biabanghard

Azari

et al. 2020

J Cardiovasc Thorac Res

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Introduction: Aging-dependent decline in the angiogenesis of heart is a risk factor for cardiovascular disease. This study was aimed to characterize effect of exercise on angiogenesis alterations and molecular mediators which are related to angiogenesis in the heart under aging condition. Methods: Twenty-one male Wistar rats were assigned into three groups: young, aged, and exercise. Aged animals in the exercise group run on treadmill for 8 weeks. At the end, heart samples were collected and used for histological evaluation , determination of angiogenesis by immunostaining for PECAM-1/ CD31 and expressions of vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-κB) levels by ELISA. P<0.05 is considered as statistically significant. Results: Our results showed that angiogenesis, and VEGF-A levels were significantly decreased, TSP1 (P>0.0001) and p-NF-κB (P>0.001) levels were significantly increased in the heart of aged group compared to young group. Exercise group showed significant increase in angiogenesis, VEGF-A (P>0.0001), and p-NF-κB (P>0.001) and showed significant decrease in TSP-1 levels (P>0.001) compared to aged group. Moreover, compared to the young group, aged group showed histological changes in the heart, such as interstitial edema, and congestion, whereas, treatment with exercise improved these undesirable changes in the heart of exercise groups. Conclusion: These findings indicated that aging-related decrease in angiogenesis in the heart may mediated by downexpression of VEGF-A and overexpression of TSP-1 proteins. Also, we showed that p-NF-κB protein was increased in the heart of aged rats, this probably mediated by compensatory mechanism. It was also showed that exercise as novel non-pharmacological therapy modifies VEGF-A and TSP-1 and increases p-NF-κB protein levels in the aged heart.

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Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats

Cited by 13 publications

References 25 publications

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

Effects of the Ingestion of Flaxseed (Linum Usitatissimum L.) Oil and Physical Exercise on the Body Weight, Glycemic and Lipid Profiles of a Rat Model Developed for the Study of Metabolic Syndrome

No evidence for change in expression of TBC1D1 and TBC1D4 genes in cultured human adipocytes stimulated by myokines and adipokines

Exercise improves aging-related decreased angiogenesis through modulating VEGF-A, TSP-1 and p-NF-Ƙb protein levels in myocardiocytes

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