Therapeutic and Preventive Effect of Voluntary Running Wheel Exercise on Social Defeat Stress (SDS)-induced Depressive-like Behavior and Chronic Pain in Mice

Pagliusi, Marco; Bonet, Ivan José Magayewski; Brandao, Arthur Freitas; Magalhães, Silviane Fernandes de; Tambeli, Cláudia Herrera; Sartori, César Renato

doi:10.1016/j.neuroscience.2019.12.037

Cited by 24 publications

(22 citation statements)

References 63 publications

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“…The potential benefits of susceptibility, in terms of increased threat avoidance, appear to come at some cost, as these animals also had reduced weight gain and increased pain sensitivity following CSDS. Other studies have observed overall increased pain sensitivity following defeat (Marco Pagliusi et al, 2020 ; M Pagliusi et al, 2020 ), but it is unclear whether individual variation in pain sensitivity precedes the defeat; additional studies are needed to uncover whether this is a predictive factor. Taken together, our results suggest that susceptibility should be viewed in a more nuanced way, as the conditions in which the observed behavior is expressed dictates whether there it is a cost or benefit to the animal.…”

Section: Discussionmentioning

confidence: 99%

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

Murra

Hilde

Fitzpatrick

et al. 2022

Neurobiology of Stress

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Section: Discussionmentioning

confidence: 99%

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

Murra

Hilde

Fitzpatrick

et al. 2022

Neurobiology of Stress

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“…We think this discrepancy may be due to a relative lack of stress, as Yu et al reported effects of Val66Met on open field center time only in stressed mice ( Yu et al, 2012 ). We did not use a stress model in our study; while mice are individually housed and received three injections, both of which are presumably stressful, there is substantial evidence that VWRA alleviates effects of stress on mice ( Huang et al, 2017 ; Pagliusi et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

BDNF Val66Met Polymorphism Reduces the Fatigue-Like Effects of 5-Fluorouracil on Voluntary Wheel-Running Activity in Mice

Wolff

Allen

Feng

et al. 2022

Front. Behav. Neurosci.

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Fatigue is a persistent and debilitating symptom following cancer treatments such as chemotherapy. Recent clinical studies have suggested a common single-nucleotide polymorphism of brain-derived neurotrophic factor (BDNF), Val66Met (rs6265), may be related to the severity of fatigue following cancer treatment. In this study, we tested transgenic mice homozygous for the human Val66Met BDNF gene and wild-type controls. We injected three doses of 5-fluorouracil (5FU) as a model of chemotherapy treatment, and we used changes in voluntary wheel running activity (VWRA) as a measure of fatigue-like behavior. Prior to 5FU injection, we found that during the baseline wheel-running period, the Val66Met mice lost more weight than WT controls. We next administered 5FU and saw a robust fatigue-like phenotype that lasted about 2 weeks. During the first week, the fatigue-like phenotype was less severe in the Val66Met mice and unrelated to the age of the mice. In contrast, during the second week after 5FU treatment, the fatigue-like phenotype was unrelated to the BDNF genotype but was more severe in middle aged mice compared to young mice. We conclude that the BDNF polymorphism may play a direct, protective role against chemotherapy-induced fatigue.

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“…The potential benefits of susceptibility, in terms of heightened threat discrimination, appear to come at some cost, as these animals also had reduced weight gain and increased pain sensitivity following CSDS. Other studies have observed overall increased pain sensitivity following defeat (Marco Pagliusi et al, 2020;M Pagliusi et al, 2020), but it is unclear whether individual variation in pain sensitivity precedes the defeat; additional studies are needed to uncover whether this is a predictive factor. Thus, as defined in the context of CSDS, susceptibility should be viewed in a nuanced way, in terms of costbenefit, based on the conditions in which the behavior is expressed.…”

Section: Evaluating the Cost-benefit Balance In Susceptible Micementioning

confidence: 99%

Characterizing the Behavioral and Neuroendocrine Features of Susceptibility and Resilience to Social Stress

Murra

Hilde

Fitzpatrick

et al. 2021

Preprint

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Evaluating and coping with stressful social events as they unfold is a critical strategy in overcoming them without long-lasting detrimental effects. Individuals display a wide range of responses to stress, which can manifest in a variety of outcomes for the brain as well as subsequent behavior. Chronic Social Defeat Stress (CSDS) in mice has been widely used to model individual variation following a social stressor. Following a course of repeated intermittent psychological and physical stress, mice diverge into separate populations of social reactivity: resilient (socially interactive) and susceptible (socially avoidant) animals. A rich body of work reveals distinct neurobiological and behavioral consequences of this experience that map onto the resilient and susceptible groups. However, the range of factors that emerge over the course of defeat have not been fully described. Therefore, in the current study, we focused on characterizing behavioral, physiological, and neuroendocrine profiles of mice in three separate phases: before, during, and following CSDS. We found that following CSDS, traditional read-outs of anxiety-like and depression-like behaviors do not map on to the resilient and susceptible groups. By contrast, behavioral coping strategies used during the initial social stress encounter better predict which mice will eventually become resilient or susceptible. In particular, mice that will emerge as susceptible display greater escape behavior on Day 1 of social defeat than those that will emerge as resilient, indicating early differences in coping mechanisms used between the two groups. We further show that the social avoidance phenotype in susceptible mice is specific to the aggressor strain and does not generalize to conspecifics or other strains, indicating that there may be features of threat discrimination that are specific to the susceptible mice. Our findings suggest that there are costs and benefits to both the resilient and susceptible outcomes, reflected in their ability to cope and adapt to the social stressor.

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Therapeutic and Preventive Effect of Voluntary Running Wheel Exercise on Social Defeat Stress (SDS)-induced Depressive-like Behavior and Chronic Pain in Mice

Cited by 24 publications

References 63 publications

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress

BDNF Val66Met Polymorphism Reduces the Fatigue-Like Effects of 5-Fluorouracil on Voluntary Wheel-Running Activity in Mice

Characterizing the Behavioral and Neuroendocrine Features of Susceptibility and Resilience to Social Stress

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