volume 270, issue 1-2, P167-174 2004
DOI: 10.1016/j.ijpharm.2003.11.001
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Abstract: Solid dispersions of theophylline with chitosan as a carrier were prepared using a spray-drying method. Chitosan dissolved in an acid solution forms a gel, but it does not dissolve in an alkaline solution. Therefore, drugs which form composite particles with chitosan would gradually be released in an acid solution, and are expected to have considerably sustained release in an alkaline solution. In this study, we aimed to apply this ability to sustained release pharmaceutics. In this study, we used theophylline…

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