Theileria-transformed bovine leukocytes have cancer hallmarks

Tretina, Kyle; Gotia, Hanzel T.; Mann, David J.; Silva, Joana C.

doi:10.1016/j.pt.2015.04.001

Cited by 101 publications

(124 citation statements)

References 97 publications

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“…Theileria parva is found in east, central, and southern Africa and causes East Coast fever, while Theileria annulata occurs in the Mediterranean and Middle East area, northern Africa, India, and the Far East and is the causative agent of tropical theileriosis (1). Theileria-infected cells share several hallmarks of cancer cells, such as resistance to apoptosis, uncontrolled and unlimited proliferation, deregulation of cellular energetics, and acquisition of an invasive and metastatic phenotype (2). Currently, there are different strategies for the prevention and treatment of bovine theileriosis, namely, (i) targeting the tick vector by acaricide treatment (3) or (ii) targeting the parasite itself by vaccination, chemotherapy, or a combination of the two (4,5).…”

mentioning

confidence: 99%

In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts

Hostettler

Müller

Hemphill

2016

Antimicrob Agents Chemother

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mentioning

confidence: 99%

In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts

Hostettler

Müller

Hemphill

2016

Antimicrob Agents Chemother

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“…No specific information is available regarding the pathogenesis of T. taurotragi infection. Moreover, as recently reported by Tretina et al (2015), some species of the genus Theileria, including T. parva and T. annulata, infect leukocytes inducing phenotype changes like cancer, mostly immortalization, hyperproliferation, and dissemination, even if the parasite proteins directly responsible for these changes remain unknown. A similar cancer like immunologic mechanism in T. taurotragi infection cannot be excluded.…”

mentioning

confidence: 89%

Severe meningeal fibrinoid vasculitis associated with Theileria taurotragi infection in two short-horned Zebu cattle

Biasibetti

Sferra

Lynen³

et al. 2016

Trop Anim Health Prod

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The Authors describe a severe vasculitis with fibrinoid necrosis of the meningeal arteries observed in two brains of indigenous short-horn zebu (Bos indicus) cattle, with bovine cerebral theileriosis (BCT) caused by a tick-transmitted hemoprotozoan, Theileria taurotragi, from Northern Tanzania. In the Author's opinion, the role of T. taurotragi infection in the angiocentric and angiodestructive detected features remains to be evaluated. A possible immunopathologic cancerous mechanism, secondary to the lymphoid deregulation, could be involved. This report suggests further studies to better characterize the lymphoid cell involvement in the pathogenesis of the meningeal vascular lesions by T. taurotragi.

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“…Unlike most other apicomplexan parasites, Theileria cells are not surrounded by a parasitophorous vacuole but reside instead directly in the host cell cytoplasm. They can thus directly interact with host cell signalling molecules, making them a fascinating example of a eukaryotic pathogen able to significantly manipulate and transform its host cells [102]. …”

Section: Pathogens Subvert Host Pak1 For a Range Of Functionsmentioning

confidence: 99%

Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens

et al. 2017

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Intracellular pathogens have evolved a wide range of strategies to not only escape from the immune systems of their hosts, but also to directly exploit a variety of host factors to facilitate the infection process. One such strategy is to subvert host cell signalling pathways to the advantage of the pathogen. Recent research has highlighted that the human serine/threonine kinase PAK, or p21-activated kinase, is a central component of host-pathogen interactions in many infection systems involving viruses, bacteria, and eukaryotic pathogens. PAK paralogues are found in most mammalian tissues, where they play vital roles in a wide range of functions. The role of PAKs in cell proliferation and survival, and their involvement in a number of cancers, is of great interest in the context of drug discovery. In this review we discuss the latest insights into the surprisingly central role human PAK1 plays for the infection by such different infectious disease agents as viruses, bacteria, and parasitic protists. It is our intention to open serious discussion on the applicability of PAK inhibitors for the treatment, not only of neoplastic diseases, which is currently the primary objective of drug discovery research targeting these enzymes, but also of a wide range of infectious diseases.

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Theileria-transformed bovine leukocytes have cancer hallmarks

Cited by 101 publications

References 97 publications

In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts

In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts

Severe meningeal fibrinoid vasculitis associated with Theileria taurotragi infection in two short-horned Zebu cattle

Subverting Host Cell P21-Activated Kinase: A Case of Convergent Evolution across Pathogens

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