The zoonotic potential of Lactococcus garvieae: An overview on microbiology, epidemiology, virulence factors and relationship with its presence in foods

Gibello, Alicia; Galán-Sánchez, Fátima; Blanco, M. Mar; Rodríguez-Iglesias, Manuel; Domı́nguez, Lucas; Fernández‐Garayzábal, J. F.

doi:10.1016/j.rvsc.2016.09.010

Cited by 95 publications

(110 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to causing monetary damage to the ever-growing aquaculture industry globally, it is considered an emerging zoo notic agent placing immunocompromised individuals at risk (Gibello et al 2016). Application of chemotherapeutic agents is effective under experimental conditions, but is ultimately an unsustainable strategy in the control of lactococcosis due to the development and spread of antibiotic resistance.…”

Section: Resultsmentioning

confidence: 99%

“…Apart from the reputation of L. garvieae as a fish pathogen contributing to economic losses, the involvement of L. garvieae in hu man clinical infections has been well documented (Chan et al 2011). An increasing number of human infections due to L. garvieae has been re ported in recent years, where hand ling and ingestion of raw fish is re ported as a source or risk factor in the majority of clinical cases (Gibello et al 2016), giving rise to the status of an emerging zoonotic pathogen. However, foodborne transmission of L. garvieae from aquatic products is mostly deduced from patients' clinical histories and isolates are often not further characterised on a molecular level.…”

Section: Host Rangementioning

confidence: 99%

See 1 more Smart Citation

Lactococcus garvieae: an emerging bacterial pathogen of fish

Meyburgh

Bragg²,

Boucher³

2017

Dis. Aquat. Org.

122

View full text Add to dashboard Cite

Lactococcus garvieae is the causative agent of lactococcosis, a hyperacute, haemorrhagic septicaemia of fish. This bacterium is also considered an emerging zoonotic pathogen, as reports of human infection are increasing. Significant economic loss in aquaculture is suffered as a result of lactococcosis, as numerous freshwater and marine species of commercial interest are affected. Development of antibiotic resistance in L. garvieae to several chemotherapeutic agents complicates and restricts treatment options. Effective, sustainable treatment and prevention options are thus needed, but progress is impeded by the lack of knowledge concerning several aspects of the disease and the pathogen. This review aims to present the latest research on L. garvieae, with specific focus on pathogenesis, virulence factors, risks associated with chemotherapeutic administration and possible control options.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Host Rangementioning

confidence: 99%

Lactococcus garvieae: an emerging bacterial pathogen of fish

Meyburgh

Bragg²,

Boucher³

2017

Dis. Aquat. Org.

122

View full text Add to dashboard Cite

show abstract

“…; Gibello et al . ). In addition to its relevance as a pathogen, L. garvieae can also be isolated from rivers and sewage waters (Aguado‐Urda et al .…”

Section: Introductionmentioning

confidence: 97%

How does temperature influences the development of lactococcosis? Transcriptomic and immunoproteomic in vitro approaches

Castro

Reguera-Brito

López-Campos

et al. 2017

Journal of Fish Diseases

View full text Add to dashboard Cite

Lactococcus garvieae is the aetiological agent of lactococcosis, a haemorrhagic septicaemia that affects marine and freshwater fish, with special incidence and economic relevance in farmed rainbow trout. Water temperature is one of the most important predisposing factors in the development of lactococcosis outbreaks. Lactococcosis in trout usually occur when water temperatures rise to about 18 °C, while fish carriers remain asymptomatic at temperatures below 13 °C. The aim of this work was to analyse the differences in the complete transcriptome response of L. garvieae grown at 18 °C and at 13 °C and to identify the immunogenic proteins expressed by this bacterium at 18 °C. Our results show that water temperature influences the expression of L. garvieae genes involved in the lysis of part of the bacterial cell population and in the cold response bacterial adaptation. Moreover, the surface immunogenic protein profile at 18 °C suggests an important role of the lysozyme-like enzyme, WxL surface proteins and some putative moonlighting proteins (proteins with more than one function, usually associated with different cellular locations) as virulence factors in L. garvieae. The results of this study could provide insights into the understanding of the virulence mechanisms of L. garvieae in fish.

show abstract

“…garvieae is an α-haemolytic bacterium, and has three genes (hly1, hly2, hly3) which are responsible for haemolytic activity (Gibello et al, 2016). For this reason, these hly genes are used as genetic determinants in the detection of the haemolytic effect.…”

Section: Discussionmentioning

confidence: 99%