The zerovalent iron nanoparticle causes higher developmental toxicity than its oxidation products in early life stages of medaka fish

Chen, Pei‐Jen; Wu, Wei; Wu, Kevin C.‐W.

doi:10.1016/j.watres.2012.12.043

Cited by 84 publications

(31 citation statements)

References 41 publications

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“…This could dramatically increase the actual Ag concentrations locally at the biological surface and lead to mechanical disruption and blocking of biological functions. The latter phenomenon has also been suggested, e.g., by (Chen et al 2013) which found significantly elevated bioaccumulation of iron in medaka fish in exposed to agglomerating nFe 3 O 4 . In contrast, lower Fe bioaccumulation was recorded at stable colloid of Fe0 (Chen et al 2013).…”

Section: Resultsmentioning

confidence: 54%

Assessment of silver nanoparticle toxicity for common carp (Cyprinus carpio) fish embryos using a novel method controlling the agglomeration in the aquatic media

Opršal

Bláha

Pouzar

et al. 2015

Environ Sci Pollut Res

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Formation of agglomerates and their rapid sedimentation during aquatic ecotoxicity testing of nanoparticles is a major issue with a crucial influence on the risk assessment of nanomaterials. The present work is aimed at developing and testing a new approach based on the periodic replacement of liquid media during an ecotoxicological experiment which enabled the efficient monitoring of exposure conditions. A verified mathematical model predicted the frequencies of media exchanges which checked for formation of agglomerates from silver nanoparticles AgNP with 50 nm average size of the original colloid. In the model experiments, embryos of common carp Cyprinus carpio were exposed repeatedly for 6 h to AgNPs (5-50 μm Ag L(-1)) either under semistatic conditions (exchange of media after 6 h) or in variants with frequent media exchanges (varying from 20 to 300 min depending on the AgNP colloid concentration and the desired maximum agglomerate size of 200 or 400 nm). In contrast to other studies, where dissolved free metals are usually responsible for toxic effects, our 144-h experiments demonstrated the importance of AgNP agglomerates in the adverse effects of nanosilver. Direct adsorption of agglomerates on fish embryos locally increased Ag concentrations which resulted in pronounced toxicity particularly in variants with larger 400 nm agglomerates. The present study demonstrates the suitability of the novel methodology in controlling the conditions during aquatic nanomaterial toxicity testing. It further provided insights into the mechanisms underlying the effects of AgNP, which rank on a global scale among the most widely used nanomaterials.

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Section: Resultsmentioning

confidence: 54%

Assessment of silver nanoparticle toxicity for common carp (Cyprinus carpio) fish embryos using a novel method controlling the agglomeration in the aquatic media

Opršal

Bláha

Pouzar

et al. 2015

Environ Sci Pollut Res

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“…12 Li et al 21 indicated that FeNPs disturbed defense systems in embryos of medaka fish. Chen et al 14 further found that Fe 0 NPs had significant adverse effects on heart rates and eye sizes in early stages of medaka fish.…”

Section: Introductionmentioning

confidence: 97%

“…However, despite the low cost and high efficiency of Fe 0 NPs in removing contaminants, [1][2][3][4][5][6] there are concerns that Fe 0 NP application contributes to long-term impacts on environmental and human health risks. [7][8][9][10][11][12][13][14][15][16][17] Moreover, the increasing use of Fe 0 NPs in in situ groundwater remediation could lead to large numbers of NPs released into the environment and is highly likely to pose potential exposure risks. 8 Several studies have indicated that Fe 0 NPs could cause cytotoxicity in human bronchial epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Yang¹,

Lin²,

Liao³

2017

IJN

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Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe 0 ) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe 0 NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe 0 NPs in C. elegans . Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe 0 NPs were ~50 and ~5×10 −3 , respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19–5.2), 3.84 (0.38–42), and 6.78 (2.58–21) μg·g −1 , respectively, implicating that fertility is the most sensitive endpoint in C. elegans . Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe 0 NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine.

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“…Most studies focus on single size of NP to construct the relationship between metal NP concentration and their adverse effects. Recently, several studies have paid attention on investigation of behavior, mortality, development, and histopathological effects of iron, zinc, copper, and titanium NPs on zebrafish, medaka, and rainbow trout (Griffitt et al, 2008(Griffitt et al, , 2009Chen et al, 2012Chen et al, , 2013Shaw et al, 2012;Isani et al, 2013).…”

Section: Size-dependent Toxicitymentioning

confidence: 99%

Toxicokinetic Modeling Challenges for Aquatic Nanotoxicology

Chen

2016

Front. Mar. Sci.

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Nanotoxicity has become of increasing concern since the rapid development of metal nanoparticles (NPs). Aquatic nanotoxicity depends on crucial qualitative and quantitative properties of nanomaterials that induce adverse effects on subcellular, tissue, and, organ level. The dose-response effects of size-dependent metal NPs, however, are not well investigated in aquatic organisms. In order to determine the uptake and elimination rate constants for metal NPs in the metabolically active/detoxified pool of tissues, a one-compartmental toxicokinetic model can be applied when subcellular partitioning of metal NPs data would be available. The present review is an attempt to describe the nano-characteristics of toxicokinetics and subcellular partitioning on aquatic organisms with the help of the mechanistic modeling for NP size-dependent physiochemical properties and parameters. Physiologically-based pharmacokinetic (PBPK) models can provide an effective tool to estimate the time course of NP accumulation in target organs and is useful in quantitative risk assessments. NP accumulation in fish should take into account different effects of different NP sizes to better understand tissue accumulative capacities and dynamics. The size-dependent NP partition coefficient is a crucial parameter that influences tissue accumulation levels in PBPK modeling. Further research is needed to construct the effective systems-level oriented toxicokinetic model that can provide a useful tool to develop quantitatively the robustly approximate relations that convey a better insight into the impacts of environmental metal NPs on subcellular and tissue/organ responses in aquatic organisms.

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The zerovalent iron nanoparticle causes higher developmental toxicity than its oxidation products in early life stages of medaka fish

Cited by 84 publications

References 41 publications

Assessment of silver nanoparticle toxicity for common carp (Cyprinus carpio) fish embryos using a novel method controlling the agglomeration in the aquatic media

Assessment of silver nanoparticle toxicity for common carp (Cyprinus carpio) fish embryos using a novel method controlling the agglomeration in the aquatic media

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Toxicokinetic Modeling Challenges for Aquatic Nanotoxicology

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